Resources and information for parents of children with cancer . . . by parents of children with cancer.

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Bibliography: Late Effects

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A bibliography of articles on cardiotoxicity is on a separate page:

2015

Neurocognitive outcome in very long-term survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only. Kanellopoulos A et al., Pediatr Blood Cancer, epub 2015 Aug 27. Abstract.

Risk of Subsequent Neoplasms During the Fifth and Sixth Decades of Life in the Childhood Cancer Survivor Study Cohort. Turcotte LM et al., J Clin Oncol. 2015 Aug 10. Abstract.

Comparative toxicity by sex among children treated for acute lymphoblastic leukemia: A report from the Children's oncology group. Meeske KA et al., Pediatr Blood Cancer, epub 2015 Jul 14. Abstract. "This study complements cancer survivorship studies that also report an increase in treatment-related late effects among females. Risk profiles appear to be different for male and female patients, with females having greater risk of developing both acute and long-term treatment-related toxicities." Abstract.

Echocardiographic detection of cardiac dysfunction in childhood cancer survivors: How long is screening required? Pediatric Blood & Cancer, epub 6 JUL 2015. Abstract.

Growth hormone therapy and risk of recurrence/progression in intracranial tumors: a meta-analysis. Shen L et al., Neurol Sci, epub 2015 Jun 6. Abstract. "Results from our analysis indicate that GHRT decreases the risk of recurrence/progression in children with intracranial tumors, craniopharyngioma, medulloblastoma, astrocytoma, or glioma. However, GHRT for pituitary adenomas, NFPA, and ependymoma was not associated with the recurrence/progression of the tumors. GH replacement seems safe from the aspect of risk of tumor progression." (Thanks to N Keene for alerting us to this article.)

Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis. Iyer NS et al., Blood, 2015 Jun 5. Abstract. "Meta-analysis of ALL survivors treated without cranial radiation demonstrated significant impairment in IQ and other neurocognitive domains. Patients and their families should be informed about these potential negative effects to encourage surveillance and educational planning. Both preventative and intervention strategies are needed."

Survivor care for pediatric cancer survivors: a continuously evolving discipline. Record EO and Meacham LR, Curr Opin Oncol, epub 2015 Jul;27(4):291-6. Abstract.

Knowledge of diagnosis, treatment history, and risk of late effects among childhood cancer survivors and parents: The impact of a survivorship clinic. Lindell RB et al., Pediatr Blood Cancer, epub2015 Apr 20. Abstract.

Survivors of standard risk acute lymphoblastic leukemia do not have increased risk for overweight and obesity compared to non-cancer peers: A report from the Children's Oncology Group. Susan J. Lindemulder et al., Pediatric Blood & Cancer Volume 62, Issue 6, pages 1035–1041, June 2015. Abstract.

Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia. Christiansen JR et al., Pediatr Blood Cancer, epub 2015 Apr 1. Abstract. Reduced VO2 max in 47% of survivors; impaired LV diastolic function; average of 23 years since diagnosis; tied to cumulative anthracycline dose of 120 mg/m2.

Concentration, Working Speed and Memory: Cognitive Problems in Young Childhood Cancer Survivors and Their Siblings. L. Wengenroth et al., Pediatric Blood & Cancer, epub 2 FEB 2015. Abstract.

Anterior Hypopituitarism in Adult Survivors of Childhood Cancers Treated With Cranial Radiotherapy: A Report From the St Jude Lifetime Cohort Study. Wassim Chemaitilly et al., JCO, epub Jan 5 2015. Abstract. "Anterior pituitary deficits are common after CRT. Continued development over time is noted for GHD and LH/FSHD with possible associations between nontreatment of these conditions and poor health outcomes." According to the article, a large percentage of affected survivors are not treated for GHD and LH/FSHD deficiencies.

Education: Cortical surface area and thickness in adult survivors of pediatric acute lymphoblastic leukemia. Christian K. Tamnes et al., Pediatric Blood & Cancer, epub 18 JAN 2015. Abstract. "ALL survivors had smaller surface area in several cortical regions and smaller surface area in prefrontal regions was associated with reported problems in executive functioning."

Assessing anthracycline-treated childhood cancer survivors with advanced stress echocardiography. A. Blythe Ryerson et al., Pediatric Blood & Cancer Volume 62, Issue 3, pages 502–508, March 2015. Abstract.

A meta-analysis of body mass index of adolescent and adult survivors of pediatric acute lymphoblastic leukemia. Nam GE et al., J Cancer Surviv, epub 2015 Jan 10. Abstract.

Evaluation of Cardiotoxicity by Tissue Doppler Imaging in Childhood Leukemia Survivors Treated with Low-Dose Anthracycline. Bayram C et al., Pediatr Cardiol, epub 2015 Jan 11. Abstract.

Myocardial iron load and fibrosis in long term survivors of childhood leukemia. Yiu-fai Cheung et al., Pediatric Blood & Cancer, epub 3 JAN 2015. Abstract. "Ventricular fibrosis may occur in long term survivors of childhood leukemias and is related to diastolic function in the absence of significant myocardial iron overload."

Cardiac function after hematopoietic cell transplantation: An echocardiographic cross-sectional study in young adults treated in childhood. M. Genberg et al., Pediatric Blood & Cancer Volume 62, Issue 1, pages 143–147, January 2015. Abstract.

Subclinical cardiotoxicity in childhood cancer survivors exposed to very low dose anthracycline therapy. Kasey Leger et al., Pediatric Blood & Cancer Volume 62, Issue 1, pages 123–127, January 2015. Abstract. "A significant proportion of patients exposed to very low doses of anthracycline demonstrate subclinical abnormalities in LV structure, despite the absence of radiation or other risk factors. While we cannot say whether these structural changes will result in clinically significant cardiac disease, the reported progressive nature of these findings raises concern that there may truly be no safe dose of anthracycline."

2014

Second cancer risk in childhood cancer survivors treated with intensity-modulated radiation therapy (IMRT). Dana L. Casey et al., Pediatric Blood & Cancer, epub 18 OCT 2014. Abstract.

Physical activity and cardiovascular risk factors in childhood cancer survivors. Megan E. Slater et al., Pediatric Blood & Cancer, epub 18 OCT 2014. Abstract.

Muscle strength, motor performance, cardiac and muscle biomarkers in detection of muscle side effects during and after acute lymphoblastic leukemia treatment in children. Akyay A et al., J Pediatr Hematol Oncol. 2014, Nov;36(8):594-8. Abstract.

The October 2014 issue of Pediatric Blood and Cancer has several articles on late effects. See this page for a list of the articles and abstracts.

Neurologic morbidity and quality of life in survivors of childhood acute lymphoblastic leukemia: a prospective cross-sectional study. Khan RB et al., J Cancer Surviv, epub 2014 Jul 10. Abstract.

Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study cohort. Stefan Essig et al., The Lancet Oncology, Volume 15, Issue 8, Pages 841 - 851, July 2014. Abstract. Data from the CCSS, 1970-1986, was filtered for patients treated in a similar manner as today's patients. "Interpretation The prevalence of adverse long-term outcomes in children treated for standard risk acute lymphoblastic leukaemia according to contemporary protocols is low, but regular care from a knowledgeable primary-care practitioner is warranted."

Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment. Mostoufi-Moab S, Halton J. Curr Osteoporos Rep, epub 2014 Jul 2. Abstract. "The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research."

Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Armenian SH et al., Clin Cancer Res, epub 2014 Jun 19. Abstract.

Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study cohort. The Lancet Oncology, Early Online Publication, 20 June 2014. Abstract. Survivors of childhood cancer diagnosed between 1970 and 1986.

Magnetic resonance imaging in the evaluation of cognitive function. Erin D. Bigler, Pediatric Blood & Cancer, epub 11 JUN 2014. Abstract.

Serum Alpha Tocopherol, Vitamin B12, and Folate Levels in Childhood Acute Lymphoblastic Leukemia Survivors With and Without Neuropathy. Jain P et al., J Child Neurol, epub 2014 May 22. Abstract. "Thus, the prevalence of deficiencies of these micronutrients was not significantly different in childhood acute lymphoblastic leukemia survivors with or without electrophysiologically defined neuropathy."

Screening for vitamin D insufficiency in pediatric cancer survivors. Adam J. Esbenshade et al., Pediatric Blood & Cancer Volume 61, Issue 4, pages 723–728, April 2014. Abstract. "VDD/VDI is equally common in pediatric cancer survivors treated with corticosteroids and healthy children. The impact of VDD/VDI in cancer survivors may be greater due to risk for impaired bone health superimposed on that conferred from corticosteroid exposure. Thus, screening VDLs should be obtained in pediatric cancer survivors treated with corticosteroids, particularly in those with elevated BMI, older age, or non-Caucasian race."

Predictors of being overweight or obese in survivors of pediatric acute lymphoblastic leukemia (ALL). Fang Fang Zhang et al., Pediatric Blood & Cancer Volume 61, Issue 7, pages 1263–1269, July 2014. Abstract.

Neuropsychology reports for childhood brain tumor survivors: Implementation of recommendations at home and school. Lorraine L.T. Cheung et al., Pediatric Blood & Cancer Volume 61, Issue 6, pages 1080–1087, June 2014. Abstract.

Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Wilburn E. Reddick et al., Pediatric Blood & Cancer Volume 61, Issue 6, pages 1074–1079, June 2014. Abstract.

Long-term follow up of bone density, general and reproductive health in female survivors after treatment for haematological malignancies. Naessén S et al., Eur J Haematol, epub 2014 Mar 20. Abstract.

Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia. Shelli R. Kesler et al., Pediatric Blood & Cancer, epub 12 MAR 2014. Abstract.

Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia. Kesler SR et al., Pediatr Blood Cancer. 2014 Mar 12. Abstract.

Signs of early sub-clinical atherosclerosis in childhood cancer survivors. Donald R. Dengel et al., Pediatric Blood & Cancer Volume 61, Issue 3, pages 532–537, March 2014. Abstract.

Bone mineral density among long-term survivors of childhood acute lymphoblastic leukemia: Results from the St. Jude Lifetime Cohort Study. Gurney JG et al., Pediatr Blood Cancer, epub 2014 Feb 28. Abstract. "Very low BMD was relatively uncommon in this sample of adult survivors of childhood ALL, and BMD Z-scores tended to improve from adolescence to young adulthood. High-dose cranial or craniospinal radiation exposure was the primary predictor of suboptimal BMD in our study. Given that cranial radiation treatment for childhood ALL is used far more sparingly now than in earlier treatment eras, concerns about persistently low BMD among most current childhood ALL patients may be unwarranted." Full Text should be available at the journal website.

A systematic review of dental late effects in survivors of childhood cancer. Prasad L. Gawade et all, Pediatric Blood & Cancer Volume 61, Issue 3, pages 407–416, March 2014. Abstract.

Obesity in Pediatric ALL Survivors: A Meta-Analysis. Zhang FF et al., Pediatrics, epub 2014 Feb 17. Abstract.

Metabolic syndrome and cardiovascular risk among long-term survivors of acute lymphoblastic leukaemia - From the St. Jude Lifetime Cohort. Nottage KA et al., Br J Haematol, epub 2014 Jan 27. Abstract.

The contribution of neurocognitive functioning to quality of life after childhood acute lymphoblastic leukemia. Kunin-Batson A, Kadan-Lottick N, Neglia JP, Psychooncology, epub 2014 Feb 4. Abstract.

Mathematics development and difficulties: The role of visual-spatial perception and other cognitive skills. Barnes MA and Raghubar KP, Pediatr Blood Cancer, epub 2014 Feb 9. Abstract.

Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Reddick WE et al., Pediatr Blood Cancer, epub 2014 Jan 25. Abstract.

Fit4Life: A weight loss intervention for children who have survived childhood leukemia. Huang JS et al., Pediatr Blood Cancer, epub 2014 Jan 16. Abstract.

Calcium and cholecalciferol supplementation provides no added benefit to nutritional counseling to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL). Kaste SC et al., Pediatr Blood Cancer, epub 2014 Jan 7. Abstract.

What the Affordable Care Act Means for Survivors of Pediatric Cancer. Emily L. Mueller et al., J Clin Oncol, epub 2014 Jan 6. Download the full-text pdf at the JCO website.

Neurocognitive and Neuroradiologic Central Nervous System Late Effects in Children Treated on Pediatric Oncology Group (POG) P9605 (Standard Risk) and P9201 (Lesser Risk) Acute Lymphoblastic Leukemia Protocols (ACCL0131): A Methotrexate Consequence? A Report From the Children's Oncology Group. Duffner PK et al., J Pediatr Hematol Oncol. 2014 Jan;36(1):8-15. Abstract.

Childhood cancer survivors exposed to total body irradiation are at significant risk for slipped capital femoral epiphysis during recombinant growth hormone therapy. Sogol Mostoufi-Moab et al., Pediatric Blood & Cancer Volume 60, Issue 11, pages 1766–1771, November 2013. Abstract.

The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: A report from the childhood cancer survivor study. Daniel M. Green et al., Pediatric Blood & Cancer Volume 61, Issue 1, pages 53–67, January 2014. Abstract.

2013

Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation. Krull KR et al., Blood. 2013 Jul 25;122(4):550-3. Abstract.

A systematic review of dental late effects in survivors of childhood cancer. Prasad L. Gawade et al., Pediatric Blood & Cancer, epub 1 NOV 2013. Abstract.

Dexamethasone exposure and memory function in adult survivors of childhood acute lymphoblastic leukemia: A report from the SJLIFE cohort. Michelle N. Edelmann et al., Pediatric Blood & Cancer Volume 60, Issue 11, pages 1778–1784, November 2013. Abstract.

Pulmonary outcomes in survivors of childhood central nervous system malignancies: A report from the childhood cancer survivor study. Tseng Tien Huang et al., Pediatric Blood & Cancer Volume 61, Issue 2, pages 319–325, February 2014. Abstract.

Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: a report from the st jude lifetime cohort study. Krull KR et al., J Clin Oncol. 2013 Dec 10;31(35):4407-15. Abstract.

Signs of early sub-clinical atherosclerosis in childhood cancer survivors. Donald R. Dengel et al., Pediatric Blood & Cancer, epub 24 OCT 2013. Abstract.

Neuropsychological outcomes of a randomized trial of prednisone versus dexamethasone in acute lymphoblastic leukemia: Findings from Dana-Farber Cancer Institute All Consortium Protocol 00-01. Deborah P. Waber et al., Pediatric Blood & Cancer Volume 60, Issue 11, pages 1785–1791, November 2013. Abstract.

Long-term follow-up of pediatric patients receiving total body irradiation before hematopoietic stem cell transplantation and post-transplant survival of >2 years. Annette KŸnkele et al., Pediatric Blood & Cancer Volume 60, Issue 11, pages 1792–1797, November 2013. Abstract.

Subsequent malignancies and their effect on survival in patients with retinoblastoma. Eric T. Shinohara et al., Pediatric Blood & Cancer Volume 61, Issue 1, pages 116–119, January 2014. Abstract.

Long-term follow-up of the thyroid gland after treatment with 131I-Metaiodobenzylguanidine in children with neuroblastoma: Importance of continuous surveillance. S.C. Clement et al., Pediatric Blood & Cancer Volume 60, Issue 11, pages 1833–1838, November 2013. Abstract.

Fatigue in adolescents with cancer compared to healthy adolescents. Lauren C. Daniel et al., Pediatric Blood & Cancer Volume 60, Issue 11, pages 1902–1907, November 2013. Abstract.

Life partnerships in childhood cancer survivors, their siblings, and the general population. L. Wengenroth et al., Pediatric Blood & Cancer, epub 18 OCT 2013. Abstract.

Innovative educational approaches to engage and empower the adolescent and young adult childhood cancer survivor. Karim Thomas Sadak et al., Pediatric Blood & Cancer Volume 60, Issue 12, pages 1919–1921, December 2013. Abstract.

Activity interventions for cognitive problems. Elizabeth R. Skidmore, Pediatric Blood & Cancer, epub 13 SEP 2013. Abstract.

Information provision and information needs in adult survivors of childhood cancer. Micòl E. Gianinazzi et al., Pediatric Blood & Cancer, epub 9 SEP 2013. Abstract.

Adequate endocrine and cardiovascular response to social stress in survivors of childhood acute lymphoblastic leukemia. Gordijn MS et al., Psychoneuroendocrinology. 2013 Dec;38(12):3145-9. Abstract. "We conclude that the endocrine and cardiovascular response to social stress are intact in survivors of childhood ALL."

Family physician preferences and knowledge gaps regarding the care of adolescent and young adult survivors of childhood cancer. Nathan PC et al., J Cancer Surviv. 2013 Sep;7(3):275-82. Abstract. Another important article, here is a direct quote: "IMPLICATIONS FOR CANCER SURVIVORS: Adult and adolescent survivors of childhood cancer who receive their follow-up care from a family physician must be empowered to choose a physician who is comfortable with caring for survivors. Further, the survivor must ensure that their physician has access to a treatment summary as well as to patient-specific recommendations for surveillance for late effects of cancer therapy."

Clinical Ascertainment of Health Outcomes Among Adults Treated for Childhood Cancer. Melissa M. Hudson et al., JAMA. 2013 Jun 12;309(22):2371-81. Abstract. This important article supports the following: "Adult survivors of childhood cancer are known to be at risk for treatment-related adverse health outcomes. A large population of survivors has not been evaluated using a comprehensive systematic clinical assessment to determine the prevalence of chronic health conditions."

Long-term risk of secondary skin cancers after radiation therapy for Hodgkin's lymphoma. Daniëls LA et al., Radiother Oncol, epub 2013 Aug 7. Abstract.

The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: A report from the childhood cancer survivor study. Daniel M. Green et al., Pediatric Blood & Cancer, epub 12 AUG 2013. Abstract.

Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: Effects of a home-based exercise program. Liisa S. Järvelä et al., Pediatric Blood & Cancer Volume 60, Issue 9, pages 1546–1551, September 2013. Abstract.

Use of zoledronic acid for treatment of chemotherapy related osteonecrosis in children and adolescents: A retrospective analysis. Bhavna Padhye et al., Pediatric Blood & Cancer Volume 60, Issue 9, pages 1539–1545, September 2013. Abstract.

Cardiotoxicity in childhood cancer survivors: A problem with long-term consequences in need of early detection and prevention. Steven E. Lipshultz, Vivian I. Franco, Thomas R. Cochran. Pediatric Blood & Cancer Volume 60, Issue 9, pages 1395–1396, September 2013. Abstract. (Comment.)

Neurocognitive function and CNS integrity in adult survivors of childhood Hodgkin lymphoma. Pinki K. Prasad, Translational Pediatrics, Vol 2, No 2 (April 2013). Abstract.

Dexamethasone exposure and memory function in adult survivors of childhood acute lymphoblastic leukemia: A report from the SJLIFE cohort. Edelmann MN et al., Pediatr Blood Cancer. 2013 Jun 18. Abstract. 38 survivors studied: "Results from this pilot study suggest that adult survivors of ALL treated with dexamethasone are at increased risk for memory deficits and altered neural activity in specific brain regions and networks associated with memory function."

Risk of subsequent malignancies in survivors of childhood leukemia. Perkins SM et al., J Cancer Surviv, epub 2013 Jun 9. Abstract. "Although survivors of childhood leukemia experience an increased rate of malignancy compared to their peers, the development of a subsequent malignancy is still a rare event. However, continued long-term follow-up is warranted."

The challenge of growth hormone deficiency diagnosis and treatment during the transition from puberty into adulthood. Elena Inzaghi and Stefano Cianfarani, Frontiers in Endocrinology, Pituitary Endocrinology, Volume 4, Article 34, March 2013. Abstract.

Long-term follow-up of children with high-risk neuroblastoma: The ENSG5 trial experience. Pediatric Blood & Cancer Volume 60, Issue 7, pages 1135–1140, July 2013. Abstract.

Gross and fine motor skills in children treated for acute lymphoblastic leukaemia. De Luca CR et al., Dev Neurorehabil. 2013 Jun;16(3):180-7. Abstract. 37 patients. "Most children treated for ALL display appropriate motor skills, yet around a quarter experience general motor difficulties."

Potential gonadotoxicity of treatment in relation to quality of life and mental well-being of male survivors of childhood acute lymphoblastic leukemia. Gunn ME et al., J Cancer Surviv, epub 2013 Apr 19. Abstract. 52 male patients treated between 1970 and 1995. "The male ALL survivors generally cope well, but increased focus on specific risk groups seems to be necessary."

Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. Girard P et al., Haematologica, epub 2013 May 3. Abstract.

Role of NOS3 DNA Variants in Externalizing Behavioral Problems Observed in Childhood Leukemia Survivors. Marcoux S et al., J Pediatr Hematol Oncol. 2013 May;35(4):e157-62. Abstract. Some association was found; NOS3 is discussed on wikipedia.

Motor Functioning During and Following Treatment With Chemotherapy for Pediatric Acute Lymphoblastic Leukemia. Green JL et al., Pediatr Blood Cancer. 2013 Apr 22:0. Abstract.

Physical Performance of Nontransplanted Childhood ALL Survivors is Comparable to Healthy Controls. Taskinen MH et al., J Pediatr Hematol Oncol. 2013 May;35(4):276-80. Abstract.

Vitamin D levels differ by cancer diagnosis and decline over time in survivors of childhood cancer. Galit P. Rosen et al., Pediatric Blood & Cancer Volume 60, Issue 6, pages 949–952, June 2013. Abstract.

Reduced Neuroanatomic Volumes in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia. Bernward Zeller et al., J Clin Oncol. 2013 Apr 15. Abstract. 130 patients diagnosed between 1970 and 2000: "Neither age at diagnosis nor treatment variables such as radiation therapy or drug dose had a major impact on neuroanatomic volumes. Neuropsychological assessment revealed reduced processing speed, executive function, and verbal learning/memory in survivors compared with controls but no difference in estimated general intellectual ability."

Evaluation of Memory Impairment in Aging Adult Survivors of Childhood Acute Lymphoblastic Leukemia Treated With Cranial Radiotherapy. Armstrong GT et al., J Natl Cancer Inst. 2013 Apr 12. Abstract.

Long term follow-up of survivors of childhood cancer: summary of updated SIGN guidance. W H B Wallace et al., BMJ 2013;346:f1190. Abstract.

Assessment of potential bias from non-participation in a dynamic clinical cohort of long-term childhood cancer survivors: Results from the St. Jude lifetime cohort study. Rohit P. Ojha et al., Pediatric Blood & Cancer Volume 60, Issue 5, pages 856–864, May 2013. Abstract.

Factors associated with poor quality of life in survivors of childhood acute lymphoblastic leukemia and lymphoma. Adriani Kanellopoulos et al., Pediatric Blood & Cancer Volume 60, Issue 5, pages 849–855, May 2013. Abstract.

Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia. Blijdorp K et al., Leuk Res. 2013 Apr;37(4):367-71. Abstract.

New health conditions identified at a regional childhood cancer survivor clinic visit. Mary-Jane Staba Hogan et al., Pediatric Blood & Cancer Pediatric Blood & Cancer Volume 60, Issue 4, pages 682–687, April 2013. Abstract.

Reduced cardiorespiratory fitness in adult survivors of childhood acute lymphoblastic leukemia. Emily S. Tonorezos et al., Pediatric Blood & Cancer, epub 15 FEB 2013. Abstract.

Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Maartje S. Gordijn et al., Pediatric Blood & Cancer Volume 60, Issue 3, pages 479–485, March 2013. Abstract. 62 children an average of 36 months off treatment were studied.

Psychoactive medication use and neurocognitive function in adult survivors of childhood cancer: A report from the childhood cancer survivor study. Tara M. Brinkman et al., Pediatric Blood & Cancer Volume 60, Issue 3, pages 486–493, March 2013. Abstract.

2012

Characterization of insulin resistance in young adult survivors of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma. Beauloye V et al., Clin Endocrinol (Oxf). 2012 Sep 12. Abstract. "Childhood ALL/NHL survivors treated by BMT/TBI frequently develop severe insulin resistance associated with peripheral-to-central fat redistribution, rather than increased total FM, and low adiponectin levels which may contribute to their increased CV risk."

Prolactin insufficiency but normal thyroid hormone levels after cranial radiotherapy in long-term survivors of childhood leukaemia. Follin C et al., Clin Endocrinol (Oxf). 2012 Nov 20. Abstract.

A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: A report from the international late effects of Childhood Cancer Guideline Harmonization Group. Leontien C.M. Kremer et al., Pediatric Blood & Cancer, epub 31 DEC 2012. Abstract.

Long-term follow-up of children with high-risk neuroblastoma: The ENSG5 trial experience. Pediatric Blood & Cancer, Lucas Moreno et al., epub 31 DEC 2012. Abstract.

Antidepressant use among survivors of childhood, adolescent and young adult cancer: A report of the childhood, adolescent and young adult cancer survivor (CAYACS) research program. Rebecca J. Deyell et al., Pediatric Blood & Cancer, epub 31 DEC 2012. Abstract.

Exercise capacity in long-term survivors of pediatric cancer: An analysis from the cardiac risk factors in childhood cancer survivors study. Angela M. Miller et al., Pediatric Blood & Cancer, epub 19 DEC 2012. Abstract.

Children's Oncology Group's 2013 blueprint for research: Survivorship and outcomes. Saro H. Armenian et al., Pediatric Blood & Cancer, epub 19 DEC 2012. Abstract. Outlines future strategies, including following survivors more closely with a LTFC (Long Term Follow-up Center) and connecting late effects with genetic susceptibility to certain drug late effects in order to create individualized treatments to prevent late effects. Emphasizes education about late effects for survivors.

Long-term skeletal consequences of childhood acute lymphoblastic leukemia in adult males: a cohort study. Mäkitie O et al., Eur J Endocrinol., epub 2012 Nov 29. Abstract.

Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia. Michelle Monje et al., Pediatric Blood & Cancer Volume 60, Issue 2, pages 301–308, February 2013. Abstract.

Prevalence of vitamin D insufficiency in survivors of childhood cancer. Abha Choudhary et al., Pediatric Blood & Cancer, epub 28 NOV 2012. Abstract. Briefly, the results suggest a high rate of vitamin D insufficiency in survivors but also in the general population. Then, "Since cancer survivors are at a higher risk for subsequent malignancies, cardiovascular disease, and low bone mineral density, all of which may be affected by 25-OH D levels [vitamin D], interventions to improve 25-OH D status in this vulnerable population are needed."

Back Pain Among Long-term Survivors of Childhood Leukemia. Bowers DC et al., J Pediatr Hematol Oncol. 2012 Nov;34(8):624-9. Abstract. "CONCLUSIONS: : This is the first study demonstrating an increased frequency of back pain among survivors of childhood ALL. Future studies are needed to better define the causes of back pain among childhood ALL survivors." 99 patients aged 13-25 years were compared with 52 siblings.

Myocardial 2D strain echocardiography and cardiac biomarkers in children during and shortly after anthracycline therapy for acute lymphoblastic leukaemia (ALL): a prospective study. Mavinkurve-Groothuis AM et al., Eur Heart J Cardiovasc Imaging, epub 2012 Oct 29. Abstract. ". . . the combination of cardiac biomarkers and myocardial 2D strain echocardiography is important in the assessment of cardiac function of children with ALL treated with anthracyclines."

Health promotion for adolescent childhood leukemia survivors: Building on prevention science and ehealth. Diane L. Elliot et al., Pediatric Blood & Cancer, epub 25 OCT 2012. Abstract.

Education: Computerized Cognitive Training in Survivors of Childhood Cancer: A Pilot Study. Hardy KK et al., J Pediatr Oncol Nurs. 2011 Jan-Feb;28(1):27-33. Abstract.

Education: A Multicenter, Randomized Clinical Trial of a Cognitive Remediation Program for Childhood Survivors of a Pediatric Malignancy. Butler RW et al., J Consult Clin Psychol. 2008 Jun;76(3):367-78. Abstract.

Blunted response to a growth hormone stimulation test is associated with unfavorable cardiovascular risk factor profile in childhood cancer survivors. Anna Petryk et al., Pediatric Blood & Cancer, epub 21 SEP 2012. Abstract.

Screening adult survivors of childhood cancer for cardiomyopathy: comparison of echocardiography and cardiac magnetic resonance imaging. Armstrong GT et al., J Clin Oncol. 2012 Aug 10;30(23):2876-84. Abstract. Lay article on this same type of screening (CMIR).

Melanoma as a subsequent neoplasm in adult survivors of childhood cancer: A report from the childhood cancer survivor study. A.S. Pappo et al., Pediatric Blood & Cancer, epub 8 AUG 2012. Abstract. "Survivors of childhood cancer have an approximate 2.5-fold increased risk of melanoma. Early screening and prevention strategies are warranted."

Health-related quality of life among survivors of aggressive non-Hodgkin lymphoma. Jensen RE et al., Cancer, epub 2012 Sep 5. Abstract.

Neurocognitive function and cns integrity in adult survivors of childhood Hodgkin lymphoma. Krull KR et al., J Clin Oncol., epub 2012 Sep 4. Abstract.

Cognitive Outcomes Following Contemporary Treatment Without Cranial Irradiation for Childhood Acute Lymphoblastic Leukemia. Conklin HM et al., J Natl Cancer Inst., epub 2012 Aug 27. Abstract. "Omitting cranial irradiation may help preserve global cognitive abilities, but treatment with chemotherapy alone is not without risks. Caregiver education and development of interventions should address both early attention deficits and cognitive late effects."

Long-term effects of cranial irradiation and intrathecal chemotherapy in treatment of childhood leukemia: a MEG study of power spectrum and correlated cognitive dysfunction. Daams M et al., BMC Neurol. 2012 Aug 28;12(1):84. Abstract.

Hypothalamic-pituitary-adrenal axis function in survivors of childhood acute lymphoblastic leukemia. Gordijn MS et al., Psychoneuroendocrinology. 2012 Sep;37(9):1448-56. Abstract.

Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors. Kathleen S. Ruccione et al., Pediatric Blood & Cancer Volume 59, Issue 4, pages 697–702, October 2012. Abstract.

Education: The impact of attention on social functioning in survivors of pediatric acute lymphoblastic leukemia and brain tumors. Katherine H. Moyer et al., Pediatric Blood & Cancer, epub 27 JUL 2012. Abstract.

Late effects of total body irradiation and hematopoietic stem cell transplant in children under 3 years of age. Jean M. Mulcahy et al., Pediatric Blood & Cancer, epub 27 JUL 2012. Abstract.

Ventricular systolic reserve in asymptomatic children previously treated with low doses of anthracyclines: A longitudinal, prospective exercise echocardiography study. Pediatric Blood & Cancer Volume 59, Issue 3, pages 548–552, September 2012. Abstract. "The decreased systolic reserve induced by a low dose of anthracycline in asymptomatic children and adolescents remains unaffected over a 5-year period, suggesting that positive outcomes in chronic cardiotoxicity would be expected in patients with mild impairment after anthracycline treatment."

Differential effects of radiotherapy on growth and endocrine function among acute leukemia survivors: A childhood cancer survivor study report. Eric J. Chow et al., Pediatric Blood & Cancer, epub 24 MAY 2012. Abstract. "Although patients treated with CRT + TBI were at greatest risk for short stature, hypothyroidism, and a reduced likelihood of pregnancy/live birth, those treated with either modality alone had significantly increased risks as well, including altered body composition."

Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia. Liisa S. Järvelä et al., Pediatric Blood & Cancer Volume 59, Issue 1, pages 155–160, 15 July 2012. Abstract. "A simple home-based exercise program was effective in improving cardiometabolic risk factor status and fitness in young adult survivors of childhood ALL. Simple exercise programs should be recommended to this population with increased risk of CVD to improve metabolic risk factor status and fitness."

Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model. Reid Hayward et al., Pediatric Blood & Cancer Volume 59, Issue 1, pages 149–154, 15 July 2012. Abstract. "Exercise training, initiated at the time treatment begins, can protect against delayed-onset anthracycline-induced cardiotoxicity in adult rats that were treated with anthracyclines as juveniles."

Endocrine response and perceived stress test during an experimental challenge task in adult survivors of a childhood cancer. Dominique Laufer et al., Pediatric Blood & Cancer, Volume 59, Issue 1, pages 138–143, 15 July 2012. Abstract.

Implementation of multi-site neurocognitive assessments within a pediatric cooperative group: Can it be done? Leanne Embry et al., Pediatric Blood & Cancer, epub 3 MAY 2012. Abstract.

High Risk of Symptomatic Cardiac Events in Childhood Cancer Survivors. van der Pal HJ et al., J Clin Oncol. 2012 Apr 2. Abstract.

Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients. Allison Yancey et al., Pediatric Blood & Cancer, epub 19 MAR 2012. Abstract.

Abdominal aortic calcification in young adult survivors of childhood acute lymphoblastic leukemia: Results from the St. Jude Lifetime Cohort study. James G. Gurney et al., Pediatric Blood & Cancer, epub 19 MAR 2012. Abstract. "We evaluated AAC in 662 adult survivors of childhood ALL (median age 31 years). AAC was present in 10% of subjects, metabolic syndrome in 36%, and low BMD in 29%."

Cardiovascular Status of Childhood Cancer Survivors Exposed and Unexposed to Cardiotoxic Therapy. Lipshultz SE et al., J Clin Oncol, epub Mar 5 2012. Abstract. "Childhood cancer survivors not receiving cardiotoxic treatments nevertheless have cardiovascular abnormalities, systemic inflammation, and an increased risk of atherosclerotic disease. Survivorship guidelines should address cardiovascular concerns, including the risk of atherosclerotic disease and systemic inflammation, in exposed and unexposed survivors."

What Happens Now? Psychosocial Care for Cancer Survivors After Medical Treatment Completion. Stanton AL, J Clin Oncol, epub Mar 2012. Abstract.

Neuropsychological outcomes of standard risk and high risk patients treated for acute lymphoblastic leukemia on Dana-Farber ALL consortium protocol 95-01 at 5 years post-diagnosis. Deborah P. Waber et al., Pediatric Blood & Cancer Volume 58, Issue 5, pages 758–765, May 2012. Abstract. Treatment from 1996-2000; "Test scores for both groups were generally at or above normative expectation, with the exception of verbal working memory, processing complex visual information, and parent ratings of metacognitive skills. After adjusting for covariates, the SR group performed better on measures of IQ and academic achievement, working memory and visual learning. Effect sizes, however, were only in the small to moderate range."

2011

Hepato-Biliary Late Effects in Survivors of Childhood and Adolescent Cancer: A Report from the Children's Oncology Group. Sharon Castellino et al., Pediatr Blood Cancer. 2010 May ; 54(5): 663–669. Abstract.

The effect of cancer therapy on fertility, the assessment of fertility and fertility preservation options for pediatric patients. Jill P. Ginsberg, Eur J Pediatr (2011) 170:703–708. Abstract.

Monitoring for Cardiovascular Disease in Survivors of Childhood Cancer: Report From the Cardiovascular Disease Task Force of the Children's Oncology Group. Sadhna M. Shankar et al., Pediatrics, Volume 121, Number 2, February 2008. Abstract.

Metabolic syndrome in adult cancer survivors: A meta-analysis. Hyun-Suk Jung et al., Diabetes Research and Clinical Practice, 95 (2012) 275–282. Abstract.

Severity of Health Conditions Identified in a Pediatric Cancer Survivor Program. Karen Wasilewski-Masker et al., Pediatr Blood Cancer 2010;54:976–982. Abstract.

Metabolic syndrome in adult cancer survivors: A meta-analysis. Hyun-Suk Jung et al., Diabetes Research and Clinical Practice Volume 95, Issue 2 , Pages 275-282, February 2012. Abstract.

Lessons From the Past: Opportunities to Improve Childhood Cancer Survivor Care Through Outcomes Investigations of Historical Therapeutic Approaches for Pediatric Hematological Malignancies. Melissa M. Hudson et al., Pediatr Blood Cancer 2012;58:334–343. Abstract.

Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia. Liisa S. Järvelä et al., Pediatric Blood & Cancer, epub 19 DEC 2011. Abstract.

Congenital Anomalies in the Children of Cancer Survivors: A Report From the Childhood Cancer Survivor Study. Lisa B. Signorello et al., J Clin Oncol. 2011 Dec 12. Abstract. "Our findings offer strong evidence that the children of cancer survivors are not at significantly increased risk for congenital anomalies stemming from their parent's exposure to mutagenic cancer treatments."

Cardiovascular Risk and Insulin Resistance in Childhood Cancer Survivors. Steinberger J et al., J Pediatr. 2011 Sep 13. Abstract.

Anthracycline-Related Cardiomyopathy After Childhood Cancer: Role of Polymorphisms in Carbonyl Reductase Genes--A report From the Children's Oncology Group. Blanco JG et al., J Clin Oncol. 2011 Nov 28. Abstract.

Adult Primary Care after Childhood Acute Lymphoblastic Leukemia. Lisa Diller, NEJM, 365; pp. 1417-1424, October 13, 2011. Abstract. (This article mentions the survivors clinics list.)

Special Series: 11th International Conference On Long-Term Complications Of Treatment Of Children And Adolescents for Cancer; Reviews. Several articles in Pediatric Blood & Cancer January 2012 Volume 58, Issue 1. Access is free; most topics are obesity related.

Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Cigdem Elbek Cubukcu et al., Pediatric Blood & Cancer Volume 58, Issue 1, pages 80–84, January 2012. Abstract.

Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia. Emily S. Tonorezos et al., Pediatric Blood & Cancer Volume 58, Issue 1, pages 31–36, January 2012. Abstract.

Physical and mental health status and health behaviors of childhood cancer survivors: Findings from the 2009 BRFSS survey. Celeste R. Phillips-Salimi et al., Pediatric Blood & Cancer, epub 19 OCT 2011. Abstract.

Gonadal function and parenthood 20 years after treatment for childhood lymphoma: A cross-sectional study. Hanne Hamre et al., Pediatric Blood & Cancer, epub 20 OCT 2011. Abstract.

Education: Long-term Neurocognitive Outcomes in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia. Kim Edelstein et al., J Pediatr Hematol Oncol Volume 33, Number 6, August 2011. Abstract.

Education: The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI. Christina Halsey et al., Journal of Hematology & Oncology 2011, 4:42, epub 13 October 2011. Abstract. "Children with ALL are at risk of CNS morbidity, regardless of the mode of CNS-directed therapy."

Empty sella/pituitary atrophy and endocrine impairments as a consequence of radiation and chemotherapy in long-term survivors of childhood leukemia. Yoshikazu Nishi et al., International Journal of Hematology, epub 10/11/2011. Abstract.

Hereditary cancer risk assessment in a pediatric oncology follow-up clinic. Sara Knapke et al., Pediatric Blood & Cancer, epub 17 AUG 2011. Abstract.

Education: Mathematics intervention for prevention of neurocognitive deficitsin childhood leukemia. Ida M. Moore et. al., Pediatric Blood & Cancer, epub 21 SEP 2011. Abstract.

Alcohol consumption and binge drinking in young adult childhood cancer survivors. Cornelia E. Rebholz et al., Pediatric Blood & Cancer, epub 29 AUG 2011. Abstract.

The current status of follow-up services for childhood cancer survivors, are we meeting goals and expectations: A report from the consortium for New England childhood cancer survivors. Lisa B. Kenney et al., Pediatric Blood & Cancer Volume 57, Issue 6, pages 1062–1066, 1 December 2011. Abstract.

Long-term endocrine side effects of childhood Hodgkin's lymphoma treatment: a review. W. van Dorp et al., Hum. Reprod. Update, epub September 6, 2011. Abstract.

Parental adjustment to the completion of their child's cancer treatment. Claire E. Wakefield et al., Pediatric Blood & Cancer Pediatric Blood & Cancer Volume 56, Issue 4, pages 524–531, April 2011. Abstract.

Growth abnormalities in pediatric all survivors exposed to lower-dose cranial radiation therapy: The need for continued surveillance. Jill H. Simmons, Pediatric Blood & Cancer Volume 56, Issue 2, pages 173–174, February 2011.

Blood pressure and body composition in long-term survivors of childhood acute lymphoblastic leukemia. Susanna J.E. Veringa et al., Cover image for Vol. 57 Issue 5 Pediatric Blood & Cancer, epub 25 JUL 2011. Abstract. "Both diastolic and systolic blood pressure are significantly increased in survivors of childhood ALL."

Education: Central nervous system late effects: A new frontier? (Commentary on Kamdar et al., page 454). Deborah P. Waber, Pediatric Blood & Cancer Volume 57, Issue 3, pages 355–356, September 2011. No abstract available. See also: Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy. Kala Y. Kamdar et al., Pediatric Blood & Cancer, epub 25 MAY 2011. Abstract.

Education: Children with Complex Medical Issues in Schools, Neuropsychologcal Descriptions and Interventions. Christine L. Castillo, editor. Springer Publishing Company, NY, 2008. Chapter 14, Leukemia; Julie K. Ries and Susan A. Scarvalone; pp. 323-352.

Education: School performance of childhood cancer survivors: mind the teenagers! Bonneau J et al., J Pediatr. 2011 Jan;158(1):135-41. Abstract.

Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS). Armenian SH et al., Blood. 2011 Aug 4;118(5):1413-20. Abstract.

Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer. Markhaba Tukenova et al., JCO Jul 1, 2010:3205. Abstract. "This study is the first, to our knowledge, to establish a relationship between the radiation dose received by the heart during radiotherapy for a childhood cancer and long-term cardiac mortality. This study also confirms a significant excess risk of cardiac mortality associated with a high cumulative dose of anthracyclines. "

Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: Associations with physical performance and chemotherapy doses. Kirsten K. Ness et al., Cancer, epub 15 JUL 2011. Abstract. "Neuromuscular impairments were prevalent in childhood ALL survivors and interfered with physical performance. Higher cumulative doses of vincristine and/or intrathecal methotrexate were associated with long-term neuromuscular impairments, which have implications on future function as these survivors age."

Second malignancies after childhood non-central nervous system solid cancer. Maule M et al., Int J Cancer. 2011 Apr 25. Abstract. Large group studied. "Children who survived a NCNSSC experience a large increased risk of developing a new malignancy, even many years after their initial diagnosis."

Ovarian Failure and Reproductive Outcomes After Childhood Cancer Treatment: Results From the Childhood Cancer Survivor Study. Daniel M. Green, et al., JCO May 10, 2009 vol. 27 no. 14 2374-2381. Abstract.

Second Neoplasms in Survivors of Childhood Cancer: Findings From the Childhood Cancer Survivor Study Cohort. Anna T. Meadows, epub March 2, 2009. Abstract.

Increased Adiposity and Altered Adipocyte Function in Female Survivors of Childhood Acute Lymphoblastic Leukaemia Treated without Cranial Radiation. J.A. Kohler et al., Horm Res Paediatr 2011; 75: 433-440. Abstract. "Childhood cancer survivors are at a substantial and increasing risk for SNs, including nonmelanoma skin cancer and meningiomas." Radiation heightens the risk.

Education: Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy. Kala Y. Kamdar et al., Pediatric Blood & Cancer, epub 25 MAY 2011. Abstract. "Neurocognitive impairment occurs in 20–40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and homocysteine elevation following methotrexate treatment. We evaluated the relationship between folate pathway polymorphisms [MTHFR] and neurocognitive impairment after childhood ALL chemotherapy."

Auditory complications in childhood cancer survivors: A report from the childhood cancer survivor study. Kimberly Whelan e tl., Pediatric Blood & Cancer Volume 57, Issue 1, pages 126–134, 15 July 2011. Abstract.

Second neoplasm in children treated in EORTC 58881 trial for acute lymphoblastic malignancies: Low incidence of CNS tumours. Marleen Renard et al., Pediatric Blood & Cancer Volume 57, Issue 1, pages 119–125, 15 July 2011. Abstract.

Education: Neurocognitive functioning and health-related behaviours in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Krull KR et al., Eur J Cancer. 2011 Mar 31. Abstract.

Introduction: Should Ovarian Failure in Survivors of Childhood Cancers Be Treated with Hormonal Therapy? Heather Appelbaum, MD (Section Editor), Journal of Pediatric and Adolescent Gynecology, Volume 24, Issue 2, Page 98 (April 2011).

Increased prevalence of chronic fatigue among survivors of childhood cancers: A population-based study. Jóhannsdóttir IM et al., Pediatr Blood Cancer. 2011 Mar 21. Abstract.

Vitamin D status in paediatric patients with cancer. Akash Sinha et al., Pediatric Blood & Cancer, first published online: 3 FEB 2011. Abstract. "Vitamin D levels are lower in survivors of childhood cancer in comparison to control children with the majority either insufficient or deficient."

Education: Either Called "Chemobrain" or "Chemofog," the Long-Term Chemotherapy-Induced Cognitive Decline in Cancer Survivors Is Real. Argyriou AA et al., J Pain Symptom Manage, 2010 Sep 9. Abstract.

Reduced incidence of second solid tumors in survivors of childhood Hodgkin's lymphoma treated without radiation therapy. P. M. Barbaro et al., Ann Oncol, first published online: March 10, 2011. Abstract.

Twenty-five year follow-up of childhood Wilms tumor: A report from the Childhood Cancer Survivor Study. Amanda M. Termuhlen et al., Pediatric Blood & Cancer, first published online: 7 MAR 2011. Abstract. WT treated from 1970 to 1986.

Theoretical and clinical implications of using an ADHD framework to understand attention, concentration, and executive functioning deficits in pediatric cancer survivors. R. Matt Alderson, Larry L. Mullins. Pediatric Blood & Cancer, first published online: 11 MAR 2011. No abstract given.

Late effects in childhood cancer survivors: A review with a framing effect bias? Christopher Fryer, Pediatric Blood & Cancer, first published online: 19 JAN 2011. Abstract. "Re-analysis of population-based studies on life-threatening toxicities from [many] publications shows that 5-year survivors have a near normal life expectancy, 75% have no severe or life-threatening treatment related toxicity and 87% remain free of a second malignancy. Children who received radiation or anthracycline >250–300 mg/m2 are at greatest risk for treatment related life-threatening toxicities."

Education: ADHD and secondary ADHD criteria fail to identify many at-risk survivors of pediatric ALL and brain tumor. Lisa S. Kahalley et al., Pediatric Blood & Cancer, first published online: 18 FEB 2011. Abstract.

A cross-sectional study of overweight in pediatric survivors of acute lymphoblastic leukemia (ALL). Erin Love et al., Pediatric Blood & Cancer, first published online: 11 FEB 2011. Abstract.

A systematic review of studies on psychosocial late effects of childhood cancer: Structures of society and methodological pitfalls may challenge the conclusions. Lasse Wegener Lund et al., Pediatric Blood & Cancer Volume 56, Issue 4, pages 532–543, April 201. Abstract.

Revaccination of children after completion of standard chemotherapy for acute lymphoblastic leukaemia: a pilot study comparing different schedules. Thomas Lehrnbecher et al., British Journal of Haematology Early View, 20 JAN 2011. Abstract. "Our randomized pilot study comparing different revaccination schedules suggests that children with ALL might be revaccinated with non-live vaccines as early as 3 months after chemotherapy."

Echocardiographic surveillance for asymptomatic late-onset anthracycline cardiomyopathy in childhood cancer survivors. Ibraheem Abosoudah et al., Pediatric Blood & Cancer, first published online: 28 JAN 2011. Abstract. "Periodic echocardiographic surveillance in childhood cancer survivors can yield abnormalities that require further evaluation. Abnormalities may become evident as early as 1 year after the conclusion of therapy and can impact even those survivors considered to be at low risk."

Education: Symptoms of attention-deficit/hyperactivity disorder in long-term survivors of childhood leukemia. Kevin R. Krull et al., Pediatric Blood & Cancer, first published online: 28 JAN 2011. Abstract. ADHD in survivors of ALL are subtlely different than usual cases.

Anthracycline-Associated Cardiotoxicity in Survivors of Childhood Cancer. Trachtenberg BH et al., Pediatr Cardiol. 2011 Jan 9. Abstract.

Significant 25-hydroxyvitamin D deficiency in child and adolescent survivors of acute lymphoblastic leukemia: Treatment with chemotherapy compared with allogeneic stem cell transplant. Jill H. Simmons et al., Pediatric Blood & Cancer, early view, published online 22 DEC 2010. Abstract. "The prevalence of vitamin D deficiency and insufficiency in ALL survivors is similar to that of the general pediatric population in the United States, and there is no difference in serum 25-hydroxyvitamin D status between chemotherapy-treated and HCT-treated ALL survivors. ALL survivors rarely meet the RDA requirements for vitamin D."

Health-related quality of life after completion of successful treatment for childhood cancer. V. Engelen et al., Pediatric Blood & Cancer, early view, published online 22 DEC 2010. Abstract.

Prospective medical assessment of adults surviving childhood cancer: Study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort Study. Melissa M. Hudson et al., Pediatr Blood Cancer, first published online: 15 DEC 2010. Abstract. PF comment: This follow-up study at St. Jude seems quite good. It only involves survivors who were treated at St. Jude, though. They contacted ex-patients who were over 10 years off treatment and asked them to participate on one of three levels: comprehensive evaluation, limited home evaluation, or survey only. Read the abstract for more details.

Hearing impairment after platinum-based chemotherapy in childhood. Einarsson Einar-Jon Msc et al., Pediatr Blood Cancer, first published online: 15 DEC 2010. Abstract.

Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. K S Baker et al., Leukemia (2010) 24, pp. 2039–2047. Abstract. "Compared with siblings, survivors had a higher frequency of diabetes, hypothyroidism, osteoporosis, exercise-induced shortness of breath, neurosensory impairments and problems with balance, tremor or weakness."

Height impairment after lower dose cranial irradiation in children with acute lymphoblastic leukemia. Arnold C. Paulino et al., Pediatric Blood & Cancer, Volume 56, Issue 2, pp. 279-281. Abstract.

Education: Educational and vocational achievement among long-term survivors of adolescent cancer in Germany. Ute Dieluweit et al., Pediatr Blood Cancer, first published online: 11 NOV 2010. Abstract. "Compared to peers from the general population, survivors of cancer during adolescence achieved higher educational and vocational levels."

Subclinical cardiac dysfunction and exercise performance in childhood cancer survivors. Enrico De Caro et al., Pediatr Blood Cancer, 2010;56:122–126. Abstract.

Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. K S Baker et al., Leukemia , (23 September 2010). Abstract.

Young age at diagnosis is a risk factor for negative late socio-economic effects after acute lymphoblastic leukemia in childhood. Anna Sällfors Holmqvist et al., Pediatr Blood Cancer. 2010;55:698–707. "Young age at diagnosis, as well as treatment with cranial irradiation, is a risk factor for socio-economic late effects after treatment for ALL in childhood." Abstract.

Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy. M.M. Geenen et al, Pediatr Blood Cancer, 2010;55:690–697. "Long-term survivors of ALL and Wilms tumor have unfavorable CRFs due to previous RT not CT." Abstract.

Low anthracyclines doses-induced cardiotoxicity in acute lymphoblastic leukemia long-term female survivors. Maria Amigoni et al., Pediatric Blood & Cancer Volume 55, Issue 7, pages 1343–1347, 15 December 2010. Abstract.

Lifetime Follow-up Care After Childhood Cancer. Richard I. Haddy, MD, and Theresa B. Haddy, MD. Journal of the American Board of Family Medicine, September–October 2010 Vol. 23 No. 5. Article.

Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Marie-Madeleine Dolmans et al., Blood First Edition Paper, prepublished online July 1, 2010. Abstract.

Secondary hematopoietic malignancies in survivors of childhood cancer: an analysis of 111 cases from the Surveillance, Epidemiology, and End Result-9 registry. Rihani R, et al. Cancer. 2010 Sep 15;116(18):4385-94. Abstract.

Increased Cardiometabolic Traits in Pediatric Survivors of Acute Lymphoblastic Leukemia Treated with Total Body Irradiation. Eric J. Chow et al., Biology of Blood and Marrow Transplantation, published online 01 June 2010. Abstract.

Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study. Van der Pal HJ, et al., Arch Intern Med. 2010 Jul 26;170(14):1247-55. Abstract.

Impaired Glucose Tolerance and Insulin Resistance in Survivors of Childhood Acute Lymphoblastic Leukemia: Prevalence and Risk Factors. Surapolchai, Pacharapan et al., Journal of Pediatric Hematology/Oncology: July 2010, Vol 32, Issue 5, pp. 383-389. Abstract.

Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy. Laura McCullough et al., Cancer, Published Online: 13 Jul 2010. Abstract.

Education: Attention and working memory abilities in children treated for acute lymphoblastic leukemia. Jason Ashford et al., Cancer, Published Online: 22 Jun 2010. Abstract.

Young age at diagnosis is a risk factor for negative late socio-economic effects after acute lymphoblastic leukemia in childhood. Anna Sällfors Holmqvist et al., Pediatric Blood & Cancer, Published Online: 29 Jun 2010. Abstract.

Secondary hematopoietic malignancies in survivors of childhood cancer. Rawad Rihani et al., Cancer, Published Online: 14 Jun 2010. Abstract.

Sperm analysis of patients after successful treatment of childhood acute lymphoblastic leukemia with chemotherapy. Adine Marquis et al., Pediatric Blood & Cancer, Volume 55 Issue 1, pp. 208 - 210, 2010. Abstract. 11 survivors studied: "This suggests that treatment with chemotherapeutic agents alone, even in moderate doses, might have a gonadotoxic effect."

Late effects and quality of life of childhood cancer survivors: Part 1. Impact of stem cell transplantation. Ishida Y et al., Int J Hematol. 2010 May 15. Abstract.

Primary care of adult survivors of childhood cancer. Seehusen DA, Baird D, Bode D, Am Fam Physician. 2010 May 15;81(10):1250-5. Abstract.

Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia. Wing Leung et al., Cancer Epidemiology, Volume 34, Issue 3, pp. 303-308 (June 2010). Abstract.

Post-thrombotic syndrome after central venous catheter removal in childhood cancer survivors is associated with a history of obstruction. Shoshana Revel-Vilk et al., Pediatric Blood & Cancer, Volume 55, Issue 1, 2010, pp. 153-156. Abstract.

Severity of health conditions identified in a pediatric cancer survivor program. Karen Wasilewski-Masker et al., Pediatric Blood & Cancer, Volume 54, Issue 7, 2010, pp. 976-982. Abstract.

Transition of Care for Young Adult Survivors of Childhood and Adolescent Cancer: Rationale and Approaches. Freyer DR. J Clin Oncol. 2010 Mar 29. Abstract.

Sperm analysis of patients after successful treatment of childhood acute lymphoblastic leukemia with chemotherapy. Adine Marquis et al., Pediatric Blood & Cancer, early view - Published Online: 22 Mar 2010. Abstract. ". . . chemotherapy regimen and compared sperm analysis to healthy men. While sex hormone levels were normal in all subjects, 5/11 survivors showed pathological sperm concentration and 4/11 a decreased total sperm count compared to WHO criteria. Compared to healthy controls, all quantitative parameters in semen analysis of survivors were decreased."

Health and risk behaviors in survivors of childhood acute myeloid leukemia: A report from the Children's Oncology Group. Kris Ann P. Schultz et al., Pediatric Blood & Cancer, Published Online: 15 Mar 2010. Abstract.

Abnormal NT-pro-BNP levels in asymptomatic long-term survivors of childhood cancer treated with anthracyclines. Annelies M.C. Mavinkurve-Groothuis et al., Pediatric Blood & Cancer, Volume 52 Issue 5, pp. 631-63, Published Online: 6 Jan 2009. Abstract. "Abnormal levels of NT-pro-BNP were detected in 13% of 122 asymptomatic, long-term survivors of childhood cancer." Associated with cumulative anthracycline dose of 300 mg/m2 or more. Also, Abnormal levels of NT-pro-BNP were " significantly related to end-diastolic left ventricular internal diameter (LVIDd) indexed for body surface area (BSA) (P<0.01)."

Long-term Mortality from Second Malignant Neoplasms in 5-Year Survivors of Solid Childhood Tumors: Temporal Pattern of Risk according to Type of Treatment. Tukenova M et al., Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):707-15. Abstract. "Five-year survivors of childhood cancer run a high long-term mortality risk for all types of second malignant neoplasms whatever the treatment received and require careful long-term screening well beyond 25 years after the diagnosis."

Cardiotoxicity After Childhood Cancer: Beginning With the End in Mind. Lipshultz SE and Adams MJ. J Clin Oncol. 2010 Mar 10;28(8):1276-81. No abstract available.

Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. Tukenova M et al., J Clin Oncol. 2010 Mar 10;28(8):1308-15. Abstract. "This study is the first, to our knowledge, to establish a relationship between the radiation dose received by the heart during radiotherapy for a childhood cancer and long-term cardiac mortality. This study also confirms a significant excess risk of cardiac mortality associated with a high cumulative dose of anthracyclines."

Education: Working memory in survivors of childhood acute lymphocytic Leukemia: Functional neuroimaging analyses. Kristen E. Robinson et al., Pediatric Blood & Cancer, Volume 54, Issue 4, 2010, pp. 585-590. Abstract.

Exercise echocardiography in asymptomatic survivors of childhood cancer treated with anthracyclines: A prospective follow-up study. Elske Sieswerda et al., Pediatric Blood & Cancer, Volume 54, Issue 4, 2010, pp. 579-584. Abstract.

2009

Late effects in long-term survivors after treatment for childhood acute leukemia. Haddy TB, Mosher RB, Reaman GH. Clin Pediatr (Phila). 2009 Jul;48(6):601-8. Abstract.

Fertility of Female Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Daniel M. Green et al., JCO, Published online before print April 13, 2009. Full text.

Diabetes Mellitus in Long-term Survivors of Childhood Cancer. Increased Risk Associated With Radiation Therapy: A Report for the Childhood Cancer Survivor Study. Lillian R. Meacham et al., Archives of Internal Medicine, Vol. 169 No. 15, Aug 10/24, 2009. Abstract.

Pediatric Cancer Survivorship: The Childhood Cancer Survivor Study
May 10, 2009 J Clin Oncol

Physician Preferences and Knowledge Gaps Regarding the Care of Childhood Cancer Survivors: A Mailed Survey of Pediatric Oncologists. J Clin Oncol. 2009 Dec 28. Abstract. Briefly, "Many [pediatric onologists] appear unfamiliar with LTFU surveillance guidelines."

Long-term cardiac follow-up of children treated with anthracycline doses of 300 mg/m2 or less for acute lymphoblastic leukemia. Mathias Rathe et al., Pediatric Blood & Cancer, Volume 54, Issue 3, 2010 pp. 444-448. Abstract. "All echocardiographic parameters including ejection fraction (EF) deteriorated significantly over time. Male gender was significantly associated with systolic dilatation of the left ventricle and positively associated with left ventricular mass. Reduction of EF was significantly associated with age at diagnosis and male gender. . . Anthracycline doses of <300 mg/m2 may contribute to a decline in cardiac function over time. Although the deterioration in cardiac parameters was not associated with clinical symptoms, life-long cardiac surveillance for these patients is important to establish the impact of low-dose anthracycline therapy on long-term cardiac health"

Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. Mulrooney DA et al., BMJ. 2009 Dec 8;339. Abstract. "Exposure to 250 mg/m(2) or more of anthracyclines increased the relative hazard of congestive heart failure, pericardial disease, and valvular abnormalities by two to five times compared with survivors who had not been exposed to anthracyclines. . . Survivors of childhood and adolescent cancer are at substantial risk for cardiovascular disease."

Fertility of Male Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Green DM et al., J Clin Oncol. 2009 Nov 30. Abstract.

Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985–2000). L B Silverman et al., Leukemia advance online publication 17 December 2. Abstract.

Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia. Mariël L. te Winkel et al., Haematologica 2009. Abstract.

Cranial irradiation does not result in pituitary-gonadal axis dysfunction in very long-term male survivors of childhood acute lymphoblastic leukemia. N J van Casteren et al., Leukemia, Dec. 2009 Volume 23 Number 12, pp. 2310–2313. Abstract.

Health-related quality of life and cognitive outcomes among child and adolescent survivors of leukemia. Shyh-Shin Chiou et al., Supportive Care in Cancer, December 01, 2009. Abstract.

Long-term population-based divorce rates among adult survivors of childhood cancer in Britain. Clare Frobisher et al., Pediatric Blood & Cancer, Volume 54, Issue 1, 2010, pp. 116-122. Abstract.

Ocular late effects in childhood and adolescent cancer survivors: A report from the childhood cancer survivor study. Kimberly F. Whelan et al., Pediatric Blood & Cancer, Volume 54, Issue 1, 2010, pp. 103-109. Abstract.

Restrictions in daily life after retinoblastoma from the perspective of the survivors. Jennifer van Dijk et al., Pediatric Blood & Cancer, Volume 54, Issue 1, 2010, pp. 110-115. Abstract.

Survey of long-term follow-up programs in the United States for survivors of childhood brain tumors. Daniel C. Bowers et al., Pediatric Blood & Cancer Volume 53, Issue 7, 2009, pp. 1295-1301. Abstract.

Weight patterns in children with higher risk ALL: A report from the Children's Oncology Group (COG) for CCG 1961. Weight patterns in children with higher risk ALL: A report from the Children's Oncology Group (COG) for CCG 1961. Janice S. Withycombe et al., Pediatric Blood & Cancer, Volume 53, Issue 7, 2009, pp. 1249-1254. "Successful treatment of higher risk childhood ALL was associated with obesity, independent of cranial irradiation. The beginning of maintenance therapy may be the best time to intervene with nutritional and behavioral interventions, particularly for children who are obese or aged 5-9 years at diagnosis, female, Black or Hispanic, or those with metabolic toxicities during induction." Abstract.

Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia. Sindhu Ramchandren et al., Journal of the Peripheral Nervous System, Volume 14 Issue 3, pp. 184-189, 2009. "Nerve conduction study abnormalities were seen in 29.7% of children who were longer than 2 years off therapy for ALL. Most children with an abnormal examination or NCS did not have subjective symptoms. Although overall motor function was below population norms on the BOT-2, presence of neuropathy did not significantly correlate with motor functional status or QOL." Abstract.

Late-Occurring Neurologic Sequelae in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study. Robert E. Goldsby et al., JCO Early Release, Nov 16 2009. Abstract. "Conclusion: Children treated with regimens that include cranial radiation for ALL and those who suffer a relapse are at increased risk for late-onset neurologic sequelae."

Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia. Nina S. Kadan-Lottick et al., JCO Early Release, published online ahead of print Nov 2 2009. Abstract.

Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood. Vladan Raji et al., Leukemia and Lymphoma, Volume 50, Issue 10 October 2009, pp. 1693-1698. Abstract.

Quality of life after successful treatment of early-stage Hodgkin's lymphoma: 10-year follow-up of the EORTC—GELA H8 randomised controlled trial. Natacha Heutte et al., The Lancet Oncology, Early Online Publication, 13 October 2009. Abstract. "...patients experience strain and limitations in all subdomains apart from cognitive functioning, and also have reduced motivation."

Ocular late effects in childhood and adolescent cancer survivors: A report from the childhood cancer survivor study. Whelan K et al., Pediatr Blood Cancer. 2009 Sep 22. Abstract.

Testicular function after treatment for acute lymphoblastic leukemia (all) in prepubertal and pubertal boys. Maryna Krawczuk-Rybak et al., Pediatric Hematology and Oncology, Volume 26, Issue 7 2009, pp 504-514. Abstract. "The results show that treatment for ALL has a negative effect on spermatogenesis, regardless of the age at treatment and type of therapy."

Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation. Kathleen A. Meeske et al., Pediatric Blood & Cancer, Volume 53, Issue 4, 2009 pp 615-621. Abstract.

Few Risks To Newborn Offspring Of Parents Who Are Childhood Cancer Survivors. Two articles in Archives of Pediatrics & Adolescent Medicine, October 2009. Abstracts from the Table of Contents. Lay article.

Cost Effectiveness and Screening Interval of Lipid Screening in Hodgkin's Lymphoma Survivors. Aileen B. Chen et al., JCO Early Release, published online ahead of print Sep 14 2009. Abstract. "Conclusion: Lipid screening in survivors of HL, with statin therapy for screen-positive patients, improves survival and is cost effective. A screening interval of 3 years seems reasonable in the long-term follow-up of survivors of HL."

Cardiac or cardiopulmonary transplantation in childhood cancer survivors: An increasing need? Gill Levitt et al, European Journal of Cancer, early online view 9/8/09. A study of 43 patients, all were treated with anthracyclines (210–750 mg/m2) and 15 received cardiac radiation. The gist of the article is the stats on transplant success and a call for the medical profession to put childhood cancer survivors on heart-donor lists rather than exclude them as unlikely candidates.

Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Eric J. Chow et al, Pediatric Blood & Cancer, Volume 53, Issue 3, 2009, pp. 432-437. Abstract. "The risk of thyroid dysfunction and thyroid cancer was increased among childhood ALL survivors treated with craniospinal radiotherapy. In these individuals, long-term surveillance is warranted as no obvious plateau in risk was seen, even after 25 years of follow-up."

Oral health and dental anomalies in patients treated for leukemia in childhood and adolescence. Jlio CÈsar Cordova Maciel et al., Pediatric Blood & Cancer, Volume 53, Issue 3, 2009, pp. 361-365. Abstract. ALL treatment causes a significant increase in the number of dental anomalies, such as cavities, decayed or missing teeth, visible plaque, and gingival bleeding.

Voxel-Based Analysis of T2 Hyperintensities in White Matter during Treatment of Childhood Leukemia. W.E. Reddick et al., American Journal of Neuroradiology, 08/11/09. Abstract. These analyses identified specific white matter tracts involving predominantly the anterior, superior, and posterior corona radiata and superior longitudinal fasciculus, which were at increased risk for the development of T2-weighted hyperintensities during therapy for childhood ALL. These vulnerable regions may be the cause of subsequent cognitive difficulties consistently observed in survivors.

Prevalence and risk factors of radiation-induced growth hormone deficiency in childhood cancer survivors: A systematic review. Mulder RL et al., Cancer Treat Rev. 2009 Jul 27. PubMed Abstract. Conclusions: "GHD is a frequent consequence after CRT in childhood cancer survivors."

Insulin Resistance and Risk Factors for Cardiovascular Disease in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia. Kevin C. Oeffinger et al., JCO Early Release, published online ahead of print Jun 29 2009. Abstract. "In a study to determine the prevalence of insulin resistance and other risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia (ALL), it was reported that ALL survivors had an increased prevalence of insulin resistance in comparison with a cohort of older individuals from the same community"

Education: A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia. Nina S. Kadan-Lottick et al., Blood First Edition Paper, prepublished online June 22, 2009. Abstract. This article concerns CCG 1922, the low-risk protocol for ALL in the early 1990s. "There were no group differences in the distribution of test scores or the parents' report of neurological complications, psychotropic drug use, and special education. Further analyses suggested for the dexamethasone group, older age of diagnosis was associated with worse neurocognitive functioning; for the prednisone group, younger age at diagnosis was associated with worse functioning. In conclusion, our study did not demonstrate any meaningful differences in long-term cognitive functioning of childhood ALL patients based on corticosteroid randomization."

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols. Martin Stanulla et al., Blood First Edition Paper, prepublished online June 17, 2009. Abstract. TPMT is discussed in a CCCF Newsletter. A good percentage of the population has the heterozygous or homozygous form of TPMT (an enzyme). The current article reports that children with these phenotypes are not more likely to get secondary cancers (especially AML and brain tumors).

Education: Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia. Marika J. Harila et all, Pediatric Blood & Cancer, Volume 53, Issue 2, 2009. Abstract.

Pediatric Blood & Cancer, Volume 53, Issue 2, 2009, has several articles on fertility issues:

Bone Morbidity in Children treated for ALL. Strauss et al., JCO Strauss et al. 19 (12): 3066. (2001. PDF full text.

Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. Olsen JH et. al., J Natl Cancer Inst. 2009 Jun 3;101(11):806-13. PubMed Abstract. "Our studies identify a putative novel mechanism of drug resistance to the key antileukemic agent ASNase and present insights into the variations in response to ASNase in childhood ALL. This provides a platform for further optimization of asparaginase therapy with the potential of decreasing morbidity and improving outcome".

The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. Robison LL et al., J Clin Oncol. 2009 May 10;27(14):2308-18. Abstract.

Follow-up care after childhood cancer: Survivors' expectations and preferences for care. Michel G et al., Eur J Cancer. 2009 Mar 26. [Epub ahead of print]. Abstract.

Negative correlation between cerebrospinal fluid tau protein and cognitive functioning in children with acute lymphoblastic leukemia. Piotr T. Protas et al, Pediatric Blood & Cancer, Volume 53, Issue 1, 2009, p. 105-8. Abstract.

Long-Term Survivors of Childhood Cancers in the United States. Mariotto AB et al, Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1033-1040. PubMed abstract.

Ovarian Failure and Reproductive Outcomes After Childhood Cancer Treatment: Results From the Childhood Cancer Survivor Study. Daniel M. Green, et al., JCO May 10, 2009 vol. 27 no. 14 2374-2381. Abstract.

Psychological Status in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study. Lonnie K. Zeltzer et al., JCO Early Release, published online ahead of print Mar 2 2009. Abstract.

Second Neoplasms in Survivors of Childhood Cancer: Findings From the Childhood Cancer Survivor Study Cohort. Anna T. Meadows et al., JCO Early Release, published online ahead of print Mar 2 2009. Abstract.

Education: Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Annemieke I. Buizer et al., Pediatric Blood & Cancer, Volume 52, Issue 4, 2009, pp. 447-454. Abstract.

Late effects on the urinary bladder in patients treated for cancer in childhood: A report from the Children's Oncology Group. Michael Ritchey et al., Pediatric Blood & Cancer, Volume 52, Issue 4, 2009, pp. 439-446. Abstract. "Childhood cancer survivors who have had pelvic or central nervous system surgery or have received alkylator-containing chemotherapy or pelvic radiotherapy as part of their cancer therapy may experience urinary bladder late effects." (The article is a review.)

Mammography rates low among childhood cancer survivors who underwent chest radiation. HemOnc today lay article. Breast Cancer Surveillance Practices Among Women Previously Treated With Chest Radiation for a Childhood Cancer, Kevin C. Oeffinger et al., JAMA. 2009;301:404-414. Abstract.

Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. S C Kaste et al., Leukemia (2009) 23, 104–108. Abstract. (Links to high blood pressure.)

Physical Activity and Quality of Life in Adult Survivors of Non-Hodgkin's Lymphoma. Keith M. Bellizzi et al., Journal of Clinical Oncology, Early Release, published online ahead of print Jan 12 2009. Abstract.

Assessment of selection bias in clinic-based populations of childhood cancer survivors: A report from the childhood cancer survivor study. Kirsten K. Ness, Pediatric Blood & Cancer, Volume 52, Issue 3, 2009, Pages: 379-386. Abstract. "Background: It is not known to what extent prevalence estimates of late effects among childhood cancer survivors derived from clinic based samples represent the actual estimates that would be derived if the entire population of childhood cancer survivors was recruited and evaluated for a particular outcome."

Education: Parental needs for information related to neurocognitive late effects from pediatric cancer and its treatment. Christine L. Trask, Jennifer J. Greene Welch, Peter Manley, Elissa Jelalian, Cindy L. Schwartz. Pediatr Blood Cancer 2009;52:273–279. Abstract.

Education: Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function. Fiona S. Anderson, Alicia S. Kunin-Batson. Pediatr Blood Cancer 2009;52:159–164. Abstract.

Long-Term Effects of High-Dose Chemotherapy and Radiation for Relapsed and Refractory Hodgkin's Lymphoma. Karyn A. Goodman et al, Journal of Clinical Oncology, Vol 26, No 32 (November 10), 2008: pp. 5240-5247. Abstract.

Total body bone measurements: A cross-sectional study in children with acute lymphoblastic leukemia during and following completion of therapy. Kara M. Kelly et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 33-38. Abstract.

Growth effects of methylphenidate among childhood cancer survivors: A 12-month case-matched open-label study. Bruce W. Jasper et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 39-43. Abstract. Methylphenidate, or MPH, is a stimulant medication. Conclusion: "Childhood cancer survivors taking MPH experience significant, though modest, deceleration of BMI and weight across the first year of MPH intervention. . . . Such findings are encouraging in light of increasing evidence that MPH mitigates some of the cognitive late-effects of cancer treatments. Nevertheless, on a case-by-case basis, clinicians should balance the intended benefits of MPH with potential growth effects in this vulnerable population".

Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. Niels J. van Casteren et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 108-112. Abstract.

A questionnaire based review of long-term follow-up programs for survivors of childhood cancer in Canada. G.M.T. Guilcher et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 113-115. Abstract. Thought in conclusion: "New models of care incorporating primary care physicians are necessary due to growing numbers of survivors."

2008

Education: Pediatric Neurocognitive Screening Method Found to Be More Accurate than Parental Observation. Krull KR et al., J Clin Oncol. 2008 Sep 1;26(25):4138-43. PubMed Abstract. Oncology Times summary by Robert H. Carlson.

Bone mineral density in young adult survivors of acute lymphoblastic leukemia. Inas H. Thomas et al. Cancer, 17 Oct 2008. Abstract. "In this long-term follow-up study of childhood ALL survivors, low BMD was found to be more prevalent than expected based on population normative data, specifically in men."

Smoking and binge drinking among Canadian survivors of childhood and adolescent cancers: A comparative, population-based study. Kendra Carswell et al., Pediatric Blood & Cancer Volume 51, Issue 2, pages 280–287, August 2008. Abstract.

Longitudinal Changes in Obesity and Body Mass Index Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study. Edward G. Garmey et al. Journal of Clinical Oncology, Vol 26, No 28 (October 1), 2008: pp. 4639-4645. Abstract. "Compared with CCSS siblings, ALL survivors who were treated with cranial radiation therapy (CRT) had a significantly greater increase in BMI . . . . The rate of BMI increase was not significantly increased for ALL survivors who were treated with chemotherapy alone. Younger age at CRT exposure significantly modified risk."

Renal late effects in patients treated for cancer in childhood: A report from the Children's Oncology Group. Deborah P. Jones et al. Pediatric Blood & Cancer, Volume 51, Issue 6, 2008, pp. 724-731. Abstract. A review article.

Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. S C Kaste et al. Leukemia advance online publication 2 October 2008. Abstract. "Thus, kidney stones in childhood ALL survivors could herald the future deterioration of renal function and development of hypertension."

Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. Mertens AC et al. J Natl Cancer Inst. 2008 Oct 1;100(19):1368-79. Epub 2008 Sep 23. PubMed abstract. "In conclusion, children and adolescents diagnosed with cancer continue to be at elevated risk for death due to recurrences of the primary disease, and as a result of late effects of therapy," the authors write.

Medical Care in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Nathan PC et al. J Clin Oncol. 2008 Sep 20;26(27):4401-9. PubMed Abstract. "Conclusion: Despite a significant risk of late effects after cancer therapy, the majority of childhood cancer survivors do not receive recommended risk-based care."

Adult survivors of childhood cancer and their parents: experiences with survivorship and long-term follow-up. Kinahan KE et al. J Pediatr Hematol Oncol. 2008 Sep;30(9):651-8. Abstract.

Education: Screening for Neurocognitive Impairment in Pediatric Cancer Long-Term Survivors. Krull KR et al. J Clin Oncol. 2008 Sep 1;26(25):4138-43. Abstract.

Education: Scholastic achievement of children with lymphoma or Wilms tumor at the end of comprehensive education - A nationwide, register-based study. Päivi M. Lähteenmäki et al. International Journal of Cancer, published online July 23, 2008. Abstract.

Long-term follow-up of renal function after high-dose methotrexate treatment in children. Marika H. Grönroos et al. Pediatric Blood & Cancer, published online June 3, 2008. Abstract. "Our results show that HD-MTX treatment significantly decreases GFR and may cause albuminuria in pediatric cancer patients several years after treatment."

Modafinil controlled severe cancer-related fatigue. Article in HemOnc Today, June 2008. The author is Gary R. Morrow; he has published several articles on cancer fatigue treatment. Ritalin can possibly help too. (Some listmembers' children have had success with Adderall too.)

Education: Neuropsychological Outcome in Chemotherapy-Only–Treated Children With Acute Lymphoblastic Leukemia. Nathalie C.A.J. Jansen et al. Journal of Clinical Oncology, Vol 26, No 18 (June 20), 2008: pp. 3025-3030. Abstract.

Cause-specific mortality and second cancer incidence after non-Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Elizabeth C. Bluhm et al. Blood, 15 April 2008, Vol. 111, No. 8, pp. 4014-4021. Abstract.

Obesity in long-term survivors of childhood acute lymphoblastic leukemia. S. Asner et al. Pediatr Blood Cancer 2008;51:118-122, 2008. Abstract.

Education: A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Catherine C. Peterson et al. Pediatric Blood and Cancer, Volume 51 Issue 1, p. 99-104, 2008. Abstract. "Results support the presence of neuropsychological and academic sequelae for ALL survivors treated solely with chemotherapy and highlight the need for ongoing follow-up of children with ALL using a standardized neuropsychological test battery and research methodology."

Cause-specific mortality and second cancer incidence after non-Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Elizabeth C. Bluhm et al. Blood, 15 April 2008, Vol. 111, No. 8, pp. 4014-4021. Abstract.

Twenty five year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Rajen Mody, Suwen Li, Douglas C Dover, Stephen Sallan, Wendy Leisenring, Kevin C Oeffinger, Yutaka Yasui, Leslie L Robison, and Joseph P Neglia. Blood, March 2008. Lay articles: American Society of Hematology and University of Michigan Health System. Astract. Results of a study of about 4000 ALL survivors diagnosed between 1970-1986.

Education: SIOP Symposium on Adolescent and Young Adult Oncology. Several articles in this special issue of Pediatric Blood and Cancer, including:

Bone mineral density deficits in survivors of childhood cancer: long-term follow-up guidelines and review of the literature. Wasilewski-Masker K et al. Pediatrics. 2008 Mar;121(3):e705-13. PubMed abstract.

Psychosocial Outcomes and Health-Related Quality of Life in Adult Childhood Cancer Survivors. Zeltzer LK et al. Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):435-46. PubMed abstract.

Timing of menarche among survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Eric J. Chow et al. Pediatric Blood and Cancer, Volume 50, Issue 4, p. 854-858. Abstract.

Decrease in peripheral muscle strength and ankle dorsiflexion as long-term side effects of treatment for childhood cancer. Annelies Hartman et al. Pediatric Blood and Cancer, Volume 50, Issue 4, Pages 833-837, 2008. Abstract.

Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma. A Andersson et al. British Journal of Cancer advance online publication 12 February 2008. Abstract.

Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood. Borgmann A, Zinn C, Hartmann R, Herold R, Kaatsch P, Escherich G, Möricke A, Henze G, von Stackelberg A; for the ALL-REZ BFM Study Group. Eur J Cancer. 2008 Jan;44(2):257-268. PubMed Abstract.

Neurodevelopmental Sequelae of Pediatric Acute Lymphoblastic Leukemia and its Treatment. Laura A. Janzen and Brenda J. Spiegler. Developmental Disabilities Research Reviews 14: 185–195 (2008). Abstract.

2007

Body composition, exercise and energy expenditure in survivors of acute lymphoblastic leukaemia. Justin T. Warner. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 456-61. Abstract.

Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease? Kevin C. Oeffinger. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 456-461. Abstract.

Skeletal toxicities of treatment in children with cancer. Sue C. Kaste. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 469-473. Abstract.

Osteoporosis in children with cancer. Inge M. van der Sluis, Marry M. van den Heuvel-Eibrink. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 474-478. Abstract.

Osteonecrosis in children and adolescents with cancer. Ronald D. Barr, Alessandra Sala. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 483-485. Abstract.

Obesity and hypertension among children after treatment for acute lymphoblastic leukemia. Chow EJ, Pihoker C, Hunt K, Wilkinson K, Friedman DL. Cancer. 2007 Nov 15;110(10):2313-2. PubMed Abstract.

In a special issue of Chronic Illness, focusing on Childhood Cancer (December 2007), are the following articles:

Failure to lactate: A possible late effect of cranial radiation. Karen Johnston et al. Pediatric Blood & Cancer, Volume 50, Issue 3, 2008. pp. 721-722. Abstract.

Endocrine Late Effects of Childhood Cancer Therapy: A Report from the Children's Oncology Group. Horm Res. 2007 Dec 5;69(2):65-74. Nandagopal R, Laverdière C, Mulrooney D, Hudson MM, Meacham L. PubMed abstract.

Education: Neuropsychological Outcomes From a Randomized Trial of Triple Intrathecal Chemotherapy Compared With 18 Gy Cranial Radiation As CNS Treatment in Acute Lymphoblastic Leukemia: Findings From Dana-Farber Cancer Institute ALL Consortium Protocol 95-01. Deborah P. Waber et al., Journal of Clinical Oncology, Vol 25, No 31 (November 1), 2007: pp. 4914-4921. Abstract.

Stress-related mental disorders in childhood cancer survivors. Nicole M. Schrag, Robert E. McKeown, Kirby L. Jackson, Steven P. Cuffe, Ronnie W. Neuberg. Pediatric Blood & Cancer Volume 50, Issue 1, 2008. Abstract. (Several other survivorship articles in the same issue.)

Young adult oncology: the patients and their survival challenges. Archie Bleyer. CA Cancer J Clin. 2007 Jul-Aug;57(4):242-55. PubMed abstract.

High-intensity strength training improves quality of life in cancer survivors. Ingrid C. De Backer et al. Acta Oncologica, Volume 46, Issue 8 2007 , pages 1143 - 1151. Abstract.

Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia. Kirsten K. Ness, K. Scott Baker, Donald R. Dengel, Nancy Youngren, Shalamar Sibley, Ann C. Mertens, James G. Gurney. Pediatric Blood and Cancer, Volume 49, Issue 7 , Pages 975 - 981. Abstract.

Long-term follow-up of children who underwent hematopoeitic cell transplant (HCT) for AML or ALL at less than 3 years of age. Joanna L. Perkins, Alicia S. Kunin-Batson, Nancy M. Youngren, Kirsten K. Ness, Kami J. Ulrich, Melissa J. Hansen, Anna Petryk, Julia Steinberger, Fiona S. Anderson, K. Scott Baker. Pediatric Blood and Cancer, Volume 49, Issue 7 , Pages 958 - 963. Abstract.

Growth and development after hematopoietic cell transplant in children. Sanders, JE. Bone Marrow Transplant. 2007 Oct 8. PubMed Abstract.

A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Leung, Wing et al. Medicine (Baltimore). 2007 Jul;86(4):215-24. PubMed Abstract.

Perspective: Is Childhood Cancer a Chronic Disease? J Ped Hem/Onc, Volume 29(9), September 2007, pp 595-597, D'Angio, Giulio J. MD.

Exercise echocardiography reveals subclinical cardiac dysfunction in young adult survivors of childhood acute lymphoblastic leukemia. M. Jarfelt, V. Kujacic, D. Holmgren, R. Bjarnason, B. Lannering. Pediatric Blood & Cancer, Volume 49, Issue 6, 2007, p. 835-840. Abstract.

B-type natriuretic peptide as a marker for cardiac dysfunction in anthracycline-treated children. Sanjeev Aggarwal, Michael D. Pettersen, Kanta Bhambhani, Joellyn Gurczynski, Ronald Thomas, Thomas L'Ecuyer. Pediatric Blood & Cancer, Volume 49, Issue 6, 2007, p. 812-816. Abstract.

Health status and quality of life in long-term survivors of childhood leukaemia: the impact of haematopoietic stem cell transplantation. Michel, G., et al. Bone Marrow Transplantation advance online publication 20 August 2007. Abstract. "In spite of a higher risk of physical adverse events in the transplanted group, very few clinically significant differences in QoL are detectable."

Education: Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer: A Report From the Children's Oncology Group. Paul C. Nathan, Sunita K. Patel, Kimberley Dilley, Robert Goldsby, Jeanne Harvey, Chad Jacobsen, Nina Kadan-Lottick, Karen McKinley, Anne K. Millham, Ida Moore, M. Fatih Okcu, Catherine L. Woodman, Pim Brouwers, and F. Daniel Armstrong, for the Children's Oncology Group. Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer. Arch Pediatr Adolesc Med. 2007; 161(8): p. 798-806. Abstract.

Long-term endocrine sequelae of childhood cancer. Rutter MM, Rose SR. Curr Opin Pediatr. 2007 Aug;19(4):480-487. PubMed Abstract.

High incidence of meningioma in cranial irradiated survivors of childhood acute lymphoblastic leukemia. Yacov Goshen et al. Pediatric Blood & Cancer, Volume 49, Issue 3 , Pages 294 - 297, 2007. Abstract.

Factors associated with health-related quality of life in pediatric cancer survivors. Kathleen A. Meeske et al. Pediatric Blood & Cancer, Volume 49, Issue 3 , Pages 298 - 305, 2006. Abstract.

Clinical heart failure in a cohort of children treated with anthracyclines: a long-term follow-up study. Van Dalen EC et. al. Eur J Cancer. 2006 Dec;42(18):3191-8. Epub 2006 Sep 20. PubMed Abstract. Comment by Steven Lipshultz on MedScape.

Long-term cardiac outcomes following low-dose anthracycline exposure. J. A. Wright, S. Reimold, A. Turoff, S. Brooks, B. Huet, D. Eshelman, N. Winick, and K. Oeffinger ASCO Meeting Abstracts. 2007; 25(18_suppl): p. 9519. Abstract.

Longitudinal evaluation of early and late anthracycline cardiotoxicity in children with AML. Ursula Creutzi et al., Pediatric Blood and Cancer, Volume 48, Issue 7, Pages 651-662. Abstract.

Late cardiac effects of anthracycline containing therapy for childhood acute lymphoblastic leukemia. Mathias Rathe et. al., Pediatric Blood and Cancer, Volume 48, Issue 7, Pages 663-667. Abstract.

Anthracycline cardiotoxicity in long-term survivors of childhood cancer: The light is not at the end of the tunnel. Melissa M. Hudson, Pediatric Blood & Cancer, Volume 48, Issue 7, Pages 649 - 650, 2007. Abstract. "This study adds to the growing evidence that even low to moderate doses of anthracyclines might lead to progressive cardiac dysfunction. It is important that children treated with anthracyclines receive life long follow-up for signs of cardiomyopathy."

Medical Assessment of Adverse Health Outcomes in Long-term Survivors of Childhood Cancer. Maud M. Geenen et al., JAMA, Vol. 297, No. 24, June 27 2007. Abstract.

Self-report of somatic symptoms in survivors of childhood cancer: Effects of adaptive style. Nichole Jurbergs et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Hypertension and prehypertension in long-term survivors of childhood and adolescent cancer. Theresa B. Haddy et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

A stress echocardiography study of cardiac function during progressive exercise in pediatric oncology patients treated with anthracyclines. Astrid M. De Souza et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Education: A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. Laura K. Campbell et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Psychological distress in long-term survivors of solid tumors diagnosed in childhood: A report from the childhood cancer survivor study. Brad J. Zebrack et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Risk of second malignant neoplasms after childhood leukemia and lymphoma: an international study. Maule, M., et al. J Natl Cancer Inst. 2007 May 16;99(10):790-800. PubMed Abstract.

QT prolongation and Torsades de Pointes in patients previously treated with anthracyclines. Trimis, Georgios MD., et al. Anticancer Drugs. 2007 Apr;18(4):493-8. PubMed Abstract.

Early indicators of dysmetabolic syndrome in young survivors of acute lymphoblastic leukemia in childhood as a target for preventing disease. Trimis, Georgios MD., et al. J Pediatr Hematol Oncol. 2007 May;29(5):309-14. PubMed Abstract.

Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma. Bassem I. Razzouk, et al. J Clin Oncol. 2007 Apr 1;25(10):1183-9. PubMed abstract.

Obesity in adult survivors of childhood acute lymphoblastic leukemia: A follow-up report from the Childhood Cancer Survivor Study. E. G. Garmey, Q. Liu, C. A. Sklar, L. R. Meacham, M. Stovall, Y. Yasui, L. L. Robison, and K. C. Oeffinger ASCO Meeting Abstracts. 2007; 25(18_suppl): p. 9518. Abstract.

Cumulative Incidence of Secondary Neoplasms as a First Event After Childhood Acute Lymphoblastic Leukemia. Nobuko Hijiya et al. JAMA. 2007;297:1207-1215. Abstract.

Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia? Best Pract Res Clin Haematol. 2007;20(1):29-37. Richard A. Larson. PubMed Abstract.

Suicidal Ideation and Attempts in Adult Survivors of Childhood Cancer. Christopher J. Recklitis, Rebecca A. Lockwood, Monica A. Rothwell, Lisa R. Diller. Journal of Clinical Oncology, Vol 24, No 24 (August 20), 2006: pp. 3852-3857. Abstract. Free full text available. Also see the related comments.

Comparison of Long-Term Neurocognitive Outcomes in Young Children With Acute Lymphatic Leukemia Treated With Cranial Radiation or High-Dose or Very High-Dose Intravenous Methotrexate. Ian J. Cohen. J Clin Oncol 25:734-735, 2007. Abstract.

Osteonecrosis in children and adolescents with cancer? An adverse effect of systemic therapy. Alessandra Sala, et al. Eur J Cancer. 2007 Mar;43(4):683-9. PubMed abstract. Offers suggestions for prevention (during treatment).

The late effects of childhood cancer therapy. Dickerman JD. Pediatrics. 2007 Mar;119(3):554-68. PubMed abstract.

Late cardiotoxicity after treatment for Hodgkin lymphoma. Berthe M. P. Aleman, et al. Blood. 2007 Mar 1;109(5):1878-86. PubMed abstract.

Mortality among 5-year survivors of cancer diagnosed during childhood or adolescence in British Columbia, Canada. Amy C. MacArthur. Pediatric Blood & Cancer, Volume 48, Issue 4, 2007, p. 460-7. Abstract.

Long-term effects of treatments for childhood cancers. Alvarez, Jorge A, et al. Curr Opin Pediatr. 2007 Feb;19(1):23-31. PubMed abstract.

Risk of a second malignant neoplasm among 5-year survivors of cancer in childhood and adolescence in British Columbia, Canada. Pediatric Blood & Cancer, Volume 48, Issue 4, 2007, Pages: 453-459. Amy C. MacArthur et al. Abstract.

2006

Experience of Fatigue in Adolescents Living With Cancer. Ream, Emma et al., Cancer Nursing, July/Aug 2006, p. 317-326.

Late-Occurring Stroke Among Long-Term Survivors of Childhood Leukemia and Brain Tumors: A Report From the Childhood Cancer Survivor Study. Journal of Clinical Oncology, Vol 24, No 33 (November 20), 2006: pp. 5277-5282, J Clin Oncol 24:5277-5282, 2006. Abstract.

Education: Comparison of Long-Term Neurocognitive Outcomes in Young Children With Acute Lymphoblastic Leukemia Treated With Cranial Radiation or High-Dose or Very High-Dose Intravenous Methotrexate. Brenda J. Spiegler, Kimberly Kennedy, Ronnen Maze, Mark L. Greenberg, Sheila Weitzman, Johann K. Hitzler, Paul C. Nathan, J Clin Oncol 24:3858-3864, 2006. Abstract.

Mortality experiences among 15+ year survivors of childhood and adolescent cancers. Shauna C.W. Lawless, Puja Verma, Daniel M. Green, Martin C. Mahoney. Pediatric Blood & Cancer, Volume 48, Issue 3 , Pages 333 - 338. Published Online: 1 Feb 2006. Abstract. Excerpt from abstract: "...overall mortality among 15+ year survivors without a relapse appears to be comparable to the general population. The leading cause of death among 15+ year survivors is second malignancy in this study, which represents a novel and important finding in terms of long-term follow-up."

Moyamoya syndrome following childhood acute lymphoblastic leukemia. Akira Kikuchi, Miho Maeda, Ryoji Hanada, Yuri Okimoto, Koichi Ishimoto, Takashi Kaneko, Koichiro Ikuta, Masahiro Tsuchida, On behalf of the Tokyo Children's Cancer Study Group (TCCSG). Pediatric Blood & Cancer, Volume 48, Issue 3 , Pages 268 - 272, Published Online: 13 Apr 2006. Abstract.

Education: Neurocognitive effects of treatment for childhood cancer. Ment Retard Dev Disabil Res Rev. 2006;12(3):184-91. Butler RW, Haser JK. PubMed abstract.

Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Peter D. Cole, Barton A. Kamen. Volume 12, Issue 3 , Pages 174 - 183. Abstract.

****Chronic Health Conditions in Adult Survivors of Childhood Cancer. Kevin Oeffinger et al. NEJM Volume 355:1572-1582, October 12, 2006, Number 15. Full Text. Abstract. "Required Reading". Perspective article in the same issue by Philip Rosoff. Full Text.

Long-term cardiac follow-up in survivors of a malignant bone tumour. C. A. J. Brouwer, J. A. Gietema, M. P. van den Berg, M. T. E. Bink-Boelkens, N. J. Elzenga, J. Haaksma, W. A. Kamps, J. M. Vonk, E. G. E. de Vries & A. Postma. Annals of Oncology Advance Access published July 20, 2006. PubMed Abstract.

Female Survivors of Childhood Cancer: Preterm Birth and Low Birth Weight Among Their Children. Lisa B. Signorello, Sarah S. Cohen, Cristina Bosetti, Marilyn Stovall, Catherine E. Kasper, Rita E. Weathers, John A. Whitton, Daniel M. Green, Sarah S. Donaldson, Ann C. Mertens, Leslie L. Robison, John D. Boice, Jr. Journal of the National Cancer Institute, Vol. 98, No. 20, 1453-1461, October 18, 2006. Abstract. Online lay summary: Radiotherapy Threatens Babies Born to Childhood Cancer Survivors. NCI Bulletin. "Women who were exposed to radiotherapy during treatment for childhood cancer - especially pelvic radiation - are more likely to deliver infants who are born prematurely."

Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer. 2006 Aug 7. Gurney JG, Ness KK, Sibley SD, O'leary M, Dengel DR, Lee JM, Youngren NM, Glasser SP, Baker KS. Abstract.

Loss of antibodies and response to (re-)vaccination in children after treatment for acute lymphocytic leukemia: a systematic review. van Tilburg CM, Sanders EA, Rovers MM, Wolfs TF, Bierings MB. Leukemia. 2006 Aug 3. Abstract.

Behavioral and educational limitations after chemotherapy for childhood acute lymphoblastic leukemia or Wilms tumor. Buizer AI, de Sonneville LM, van den Heuvel-Eibrink MM, Veerman AJ. PubMed abstract.

Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Haddy TB, Mosher RB, Nunez SB, Reaman GH. Pediatr Blood Cancer. 2006 Feb;46(2):258-61. PubMed Abstract.

Bone mineral density and bone turnover in young adult survivors of childhood acute lymphoblastic leukaemia. M Jarfelt, H Fors, B Lannering and R Bjarnason. European Journal of Endocrinology, Vol 154, Issue 2, 303-309. Abstract.

High incidence of late effects found in Hodgkin's lymphoma survivors, following recall for breast cancer screening. Greenfield DM, Wright J, Brown JE, Hancock BW, Davies HA, O'Toole L, Eiser C, Coleman RE, Ross RJ. Br J Cancer. 2006 Feb 27;94(4):469-72. PubMed abstract.

Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Bassal M, Mertens AC, Taylor L, Neglia JP, Greffe BS, Hammond S, Ronckers CM, Friedman DL, Stovall M, Yasui YY, Robison LL, Meadows AT, Kadan-Lottick NS. J Clin Oncol. 2006 Jan 20;24(3):476-83. PubMed abstract.

Decreased numbers of CD4+ T lymphocytes in peripheral blood after treatment of childhood acute lymphoblastic leukemia. Mazur B, Szczepanski T, Karpe J, Sonta-Jakimczyk D, Bubala H, Torbus M. Leukemia Research Volume 30, Issue 1 , January 2006, Pages 33-36. "The results showed that most parameters in children 1 year after ALL treatment completion were similar to healthy children. However, we observed persistently low CD4+ T cell numbers, both CD45RA+ as well as CD45RO+ subsets as compared to the control group. This might reflect decreased regenerative potential of immunological system in children 1 year after ALL treatment." PubMed abstract.

Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Reddick WE, Shan ZY, Glass JO, Helton S, Xiong X, Wu S, Bonner MJ, Howard SC, Christensen R, Khan RB, Pui CH, Mulhern RK. Cancer. 2006 Jan 12. Abstract.

2006, Feb., Pediatric Blood and Cancer. About 10 articles on childhood cancer survivorship issues.

Experience of fatigue in adolescents living with cancer. Ream E, Gibson F, Edwards J, Seption B, Mulhall A, Richardson A. Cancer Nurs. 2006 Jul-Aug;29(4):317-26. PubMed Abstract.

2005

Special Issue on Surviving Pediatric Cancer: Research Gains and Goals. J Pediatr Psychol, Contents: Volume 30, Number 1: January/February 2005. Table of Contents for this issue. Example: Neurocognitive outcomes in survivors of childhood cancer, Moore B.

Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Pediatr Blood Cancer 20 Dec 2005 46(2): p. 258. Haddy TB, Mosher RB, Nunez SB, Reaman GH. Abstract.

Health Insurance Coverage in Survivors of Childhood Cancer: The Childhood Cancer Survivor Study. Elyse R. Park, Frederick P. Li, Yan Liu, Karen M. Emmons, Arthur Ablin, Leslie L. Robison, Ann C. Mertens. Journal of Clinical Oncology, Vol 23, No 36 (December 20), 2005: pp. 9187-9197. Abstract.

Risk of Adverse Events After Completion of Therapy for Childhood Acute Lymphoblastic Leukemia. Ching-Hon Pui, Deqing Pei, John T. Sandlund, Dario Campana, Raul C. Ribeiro, Bassem I. Razzouk, Jeffrey E. Rubnitz, Scott C. Howard, Nobuko Hijiya, Sima Jeha, Cheng Cheng, James R. Downing, William E. Evans, Mary V. Relling, Melissa Hudson. Journal of Clinical Oncology, Vol 23, No 31 (November 1), 2005: pp. 7936-7941. Abstract.

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Annemieke I.  Buizer, Leo M.J.  de Sonneville, Marry M.  Van den Heuvel-Eibrink, Charles  Njiokiktjien and Anjo J.P. Veerman. Journal of the International Neuropsychological Society (2005), 11: 554-565 Cambridge University Press. Abstract.

Education: Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Maru Barrera, Amanda K. Shaw, Kathy N. Speechley, Elizabeth Maunsell, Lisa Pogany, M.Sc. Cancer Volume 104, Issue 8 , Pages 1751 - 1760. Abstract.

Late Effects of Pelvic Rhabdomyosarcoma and Its Treatment in Female Survivors. Sheri L. Spunt, Teresa A. Sweeney, Melissa M. Hudson, Catherine A. Billups, Matthew J. Krasin, Allison L. Hester. Journal of Clinical Oncology, Vol 23, No 28 (October 1), 2005: pp. 7143-7151. Abstract.

Metabolic Syndrome in Children and Adolescents With Acute Lymphoblastic Leukemia After the Completion of Chemotherapy. Journal of Pediatric Hematology/Oncology. 27(9):499-501, September 2005. Kourti, Maria MD, MSc; Tragiannidis, Athanassios MD; Makedou, Areti MD, PhD; Papageorgiou, Theodotis MD, PhD; Rousso, Israel MD, PhD; Athanassiadou, Fani PhD, MD. Abstract.

Exercise capacity in apparently healthy survivors of pediatric cancer. Enrico De Caro, Francesca Fioredda, Maria Grazia Calevo, Attilio Smeraldi, Michele Saitta, Guia Hanau, Maura Faraci 1, Francesca Grisolia, Giorgio Dini, Giacomo Pongiglione and Riccardo Haupt. Arch Dis Child. Published Online First: 27 September 2005. Abstract.

Fatigue in Long-Term Hodgkin's Disease Survivors: A Follow-Up Study. Marianne J. Hjermstad, Sophie D. Fosså, Line Oldervoll, Harald Holte, Anne B. Jacobsen, Jon H. Loge. Journal of Clinical Oncology, Vol 23, No 27 (September 20), 2005: pp. 6587-6595. Abstract.

Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT. Paivi Holtta, D.D.S., Liisa Hovi, M.D., Ph.D., Ulla M. Saarinen-Pihkala, M.D., Ph.D., Jaakko Peltola, D.D.S., Ph.D., Satu Alaluusua, D.D.S., Ph.D. Cancer Volume 103, Issue 7 , Pages 1484 - 1493. Published Online: 28 Feb 2005. Full Text.

Chronic Progressive Cardiac Dysfunction Years After Doxorubicin Therapy for Childhood Acute Lymphoblastic Leukemia. Steven E. Lipshultz, Stuart R. Lipsitz, Stephen E. Sallan, Virginia M. Dalton, Suzanne M. Mone, Richard D. Gelber, Steven D. Colan. Journal of Clinical Oncology, Vol 23, No 12 (April 20), 2005: pp. 2629-2636. Abstract. CONCLUSION: Cardiac abnormalities were persistent and progressive after doxorubicin therapy. Inadequate ventricular mass with chronic afterload excess was associated with progressive contractile deficit and possibly reduced cardiac output and restrictive cardiomyopathy. The deficits were worst after highest cumulative doses of doxorubicin, but appeared even after low doses.

Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer ZE, Robison LL, Mertens AC. J Clin Oncol. 2005 Jun 1;23(16):3733-41. CONCLUSION: Long-term survivors of childhood and adolescent cancer who were treated with RT are at highest risk for developing NMSC. Educational efforts need to be directed to this population to facilitate early diagnosis of NMSC and reduction in sun exposure. PubMed abstract.

Bone Mineral Density in Childhood Survivors of Acute Lymphoblastic Leukemia Treated without Cranial Irradiation. Bernadette M. D. Brennan, Zulf Mughal, Stephen A. Roberts, Kate Ward, Stephen M. Shalet, Tim O. B. Eden, Andrew M. Will, Richard F. Stevens, and Judith E. Adams. The Journal of Clinical Endocrinology & Metabolism 90 (2):689–694 2005. PubMed Abstract.

Limitation of ankle range of motion in survivors of acute lymphoblastic leukemia: a cross-sectional study. Wright MJ, Halton JM, Barr RD. Med Pediatr Oncol. 1999 Apr;32(4):279-82. PubMed Abstract.

Obesity in adult survivors of childhood acute lymphoblastic leukemia: areport from the Childhood Cancer Survivor Study. J Clin Oncol. 2003 Apr 1;21(7):1359-65. Full text. Also go to the PubMed Abstract and then click on "related articles".

Prevalence and Correlates of Fatigue in Long-Term Survivors of Childhood Leukemia. Kathleen A. Meeske, Stuart E. Siegel, Denise R. Globe, Wendy J. Mack, Leslie Bernstein. Journal of Clinical Oncology, Vol 23, No 24 (August 20), 2005: pp. 5501-5510. Abstract.

Psychological Issues: The Jan/Feb 2005 Journal of Pediatric Psychology has several articles on this topic. You can read the contents/abstracts on their web site: Journal of Pediatric Oncology. Especially: Neurocognitive Interventions for children and Adolescents Surviving Cancer (Butler, R and Mulhern, R).

2004

Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. Link, K. et al. J Clin Endocrinol Metab. 2004 Oct;89(10):5003-12. PubMed abstract.

Ritalin Can Help Some Child Cancer Survivors, CancerPage version. Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. Mulhern RK, Khan RB, Kaplan S, Helton S, Christensen R, Bonner M, Brown R, Xiong X, Wu S, Gururangan S, Reddick WE. J Clin Oncol. 2004 Dec 1;22(23):4743-51. PubMed Abstract.

Long-Term Survivors of Childhood Cancers: What Knowledge Have We Gained? Posted 11/23/2004, Mike M Hawkins, MedScape. From Nature Clinical Practice Oncology; reprint address - Centre for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. (Good lay version available online on MedScape 1/05.)

Chemotherapy for Bone Sarcoma Does Not Affect Fertility Rates or Childbirth. Hosalkar, Harish S MD; Henderson, Kathleen M CRNP; Weiss, Arthur MD; Donthineni, Rakesh MD; Lackman, Richard D MD. Clin Orthop. 2004 Nov; (428):256-60. 1(428):256-260, November 2004. PubMed abstract.

Childhood cancer survivors in the dark. Caprino D, Wiley TJ, Massimo L. J Clin Oncol. 2004 Jul 1;22(13):2748-50. PubMed abstract. Full text.

Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors. Oeffinger KC, Hudson MM. CA Cancer J Clin. 2004 Jul-Aug;54(4):208-36. PubMed Abstract. Full Text.

Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Maarten Mennes, MA 1, Peter Stiers, PhD 1, Erik Vandenbussche, PhD 1, Gertrui Vercruysse, MA 2, Anne Uyttebroeck, MD 2, Geert De Meyer, PhD 3, Stefaan W. Van Gool, MD, PhD. Pediatric Blood and Cancer, early view,10/2004.

Lack of benefit of early detection of relapse after completion of therapy for acute lymphoblastic leukemia. Jeffrey E. Rubnitz, MD, PhD , Nobuko Hijiya, MD, Yinmei Zhou, MS, Michaell L. Hancock, MS, Gaston K. Rivera, MD, Ching-Hon Pui, MD. Pediatric Blood and Cancer, early view, 10/2004.

Long-term Complications Following Childhood and Adolescent Cancer: Foundations for Providing Risk-based Health Care for Survivors. Kevin C. Oeffinger, MD1 and Melissa M. Hudson, MD. CA Cancer J Clin 2004; 54:208-236. Full text online.

Anthracycline Cardiotoxicity in Children. Leontine C.M. Kremer, M.D., Ph.D., and Huib N. Caron, M.D., Ph.D. N Engl J Med 351;2 July 8, 2004.

The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia. Steven E. Lipshultz, M.D., Nader Rifai, Ph.D., Virginia M. Dalton, M.S., P.N.P., Donna E. Levy, M.S., Lewis B. Silverman, M.D., Stuart R. Lipsitz, Sc.D., Steven D. Colan, M.D., Barbara L. Asselin, M.D., Ronald D. Barr, M.D., Luis A. Clavell, M.D., Craig A. Hurwitz, M.D., Albert Moghrabi, M.D., Yvan Samson, M.D., Marshall A. Schorin, M.D., Richard D. Gelber, Ph.D., and Stephen E. Sallan, M.D. N Engl J Med 351;2 July 8, 2004.

Genotoxicity of Therapeutic Intervention in Children with Acute Lymphocytic Leukemia. Sederick C. Rice1, Pamela Vacek3, Alan H. Homans1, Terri Messier2, Jami Rivers2, Heather Kendall1,4 and Barry A. Finette. Cancer Research 64, 4464-4471, July 1, 2004. Online abstract.

Health Care of Young Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study. Kevin C. Oeffinger, MD, Ann C. Mertens, PhD, Melissa M. Hudson, MD, James G. Gurney, PhD, Jacqueline Casillas, MD, Hegang Chen, PhD, John Whitton, MS6, Mark Yeazel, MD, MPH, Yutaka Yasui, PhD and Leslie L. Robison, PhD. Ann Fam Med 2004 2: 61-70. Abstract (full text available).

Long-term follow-up of survivors of childhood cancer in the UK. Taylor A, Hawkins M, Griffiths A, Davies H, Douglas C, Jenney M, Wallace WH, Levitt G. Pediatr Blood Cancer. 2004 Feb; 42(2):161-8. PubMed Abstract. Cancer page synopsis.

The Impact of Childhood Cancer on Adult Survivors’ Interpersonal Relationships. Terri Forsbach and Andrea Thompson. Child Care in Practice, Vol. 9, No. 2, 2003.

Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia. Chessells JM, Veys P, Kempski H, Henley P, Leiper A, Webb D, Hann IM. Br J Haematol. 2003 Nov;123(3):396-405. PubMed Abstract.

Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. Pui CH, Cheng C, Leung W, Rai SN, Rivera GK, Sandlund JT, Ribeiro RC, Relling MV, Kun LE, Evans WE, Hudson MM. N Engl J Med. 2003 Aug 14;349(7):640-9. Abstract.

Psychiatric hospitalizations among survivors of cancer in childhood or adolescence. Ross L, Johansen C, Dalton SO, Mellemkjaer L, Thomassen LH, Mortensen PB, Olsen JH. N Engl J Med. 2003 Aug 14;349(7):650-7. Abstract.

Height and Weight in Children Treated for Acute Lymphoblastic Leukemia: Relationship to CNS Treatment, Virginia Kimball Dalton, Montse Rue, Lewis B. Silverman, Richard D. Gelber, Barbara L. Asselin, Ronald D. Barr, Luis A. Clavell, Craig A. Hurwitz, Albert Moghrabi, Yvan Samson, Marshall Schorin, Nancy J. Tarbell, Stephen E. Sallan, Laurie E. Cohen, Journal of Clinical Oncology, Vol 21, Issue 15 (August), 2003: 2953-2960, 2003. Abstract.

Childhood Cancer Survivors' Knowledge About Their Past Diagnosis and Treatment. Nina S. Kadan-Lottick et al., JAMA. 2002;287(14):1832-1839. Abstract.

Childhood Cancer Survivors Not Screened Enough. Author is Mark W. Yeazal, article reported to be in the Dec. 15 2003 online edition of Cancer. The link given is on the CancerPage.com web site.

Endocrine complications in pediatric patients with acute lymphoblastic leukemia, Scott C. Howard, Ching-Hon Pui. Blood Reviews, 2002, 16, 225–243. (Have a pdf of this article.) PubMed abstract.

Endocrine complications of pediatric brain tumors: case series and literature review. Muirhead SE, Hsu E, Grimard L, Keene D. Pediatr Neurol. 2002 Sep;27(3):165-70. PubMed abstract.

Health issues in survivors of childhood cancer. Castellino S, Hudson MM.South Med J. 2002 Sep;95(9):977-84. Review. No abstract available (but Medscape has the article, see the web-based article.)

Disturbance of pubertal development after cancer treatment. Muller J. Best Pract Res Clin Endocrinol Metab 2002 Mar;16(1):91-103. PubMed Abstract.

Research involving long-term survivors of childhood and adolescent cancer: methodologic considerations. Robison LL. Curr Probl Cancer. 2003 Jul-Aug;27(4):212-24. PubMed Abstract. (I have a print out of this article.)

Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME Jr, Ruccione K, Smithson WA, Robison LL. J Clin Oncol. 2001 Jul 1;19(13):3163-72. PubMed abstract. Full text.

Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME Jr, Ruccione K, Smithson WA, Robison LL. J Clin Oncol 2001 Jul 1;19(13):3163-72. PubMed Abstract. Medscape

Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. Moller TR, Garwicz S, Barlow L, Falck Winther J, Glattre E, Olafsdottir G, Olsen JH, Perfekt R, Ritvanen A, Sankila R, Tulinius H; Association of the Nordic Cancer Registries.; Nordic Society for Pediatric Hematology and Oncology. J Clin Oncol 2001 Jul 1;19(13):3173-81. PubMed Abstract. Medscape

Therapy-related myelodysplasia/leukemia (t-MDS/t-AML) following treatment of children with osteosarcoma. Bhatia, S, Krailo, M, Schwartz, C, Robison, L, Meyers, P. Proceedings of the American Society of Clinical Oncology 20: 1473a. 2001. ASCO Abstract.

Treatment of orbital rhabdomyosarcoma: Survival and late effects of treatment--Results of an international workshop. Oberlin O, Rey A, Anderson J, Carli M, Raney RB, Treuner J, Stevens MC. J Clin Oncol 19(1):197-204. 2001. PubMed Abstract.

Secondary acute myelogenous leukemia in patients previously treated for childhood renal tumors: a report from the National Wilms Tumor Study Group. Shearer P, Kapoor G, Beckwith JB, Takashima J, Breslow NE, Green DM. J Pediatr Hematol Oncol 23(2):109-111. 2001. PubMed Abstract.

Low incidence of second malignant neoplasms (SMN) following childhood acute lymphoblastic leukemia (ALL). Follow-up of the Children's Cancer Group (CCG) cohort. Bhatia, S, Sather, NH, Trigg, ME, Gaynon, PS, Robison, LL. Blood 96(11): 465a. 2000. Cannot find in Blood or PubMed.

Adult psychosocial outcomes in long-term survivors of acute lymphoblastic leukaemia and Wilms' tumour: a controlled study. Mackie E, Hill J, Kondryn H, McNally R. Lancet 2000 Apr 15;355(9212):1310-4. PubMed abstract.

1999 issue of the Journal of Pediatric Oncology Nursing has several articles of interest to survivors of childhood cancer. As of 2005, these articles on not on the web site for this journal.

Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: A Children's Cancer Group report. Kaleita, TA, Reaman, GH, MacLean, WE, Sather, HN, Whitt, JK. Cancer 85(8):1859-1865. 1999. PubMed Abstract.

Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck. Raney, RB, Asmar L, Vassilopoulou-Sellin, R, Klein MJ, Donaldson SS, Green J, Heyn R, Wharam, M, Glicksman, AS, Gehan Ea, Anderson J, Maurer HM. A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS) -II and -III. Med. Pediatr. Oncol. 33: 362-371. 1999 (can't find abstract; check med pediatr oncol site)

Pregnancy outcome after treatment for Wilms tumor. A report from the National Wilms Tumor Study Group (NWTSG). Proc Am Soc Clin Oncol 18:560a. Green DM, Peabody EM, Tait PP, Norkool PA, Breslow NE. 1999. ASCO Abstract.

Long-term survivors of childhood cancer: the late effects of therapy. Schwartz CL. Oncologist 1999;4(1):45-54. PubMed abstract. I have a pdf of this article.

Limitation of ankle range of motion in survivors of acute lymphoblastic leukemia: a cross-sectional study. Wright MJ, Halton JM, Barr RD. Med Pediatr Oncol. 1999 Apr;32(4):279-82. PubMed abstract.

Smoking in adult survivors of childhood acute lymphoblastic leukemia, Tao, ML, Guo, MD, Weiss R, Byrne, Mills, JL, Robison, LL, Zeltzer, LK. 1998. JNCI 90: 219-25. PubMed Abstract. (Note - this one is important because there will be a push to educate survivors about healthy lifestyles.)

Risk of cancer among offspring of childhood-cancer survivors. Sankila R, Olsen JH, Anderson H, Garwicz S, Glattre E, Hertz H, Langmar F, Lanning M, Møller T, Tulinius H. New England Journal of Medicine, May 7, 1998 338 (19):1339.

Legal and societal issues facing survivors of childhood cancer. Monaco GP, Fiduccia D, Smith G. Pediatr Clin North Am 1997 Aug;44(4):1043-58. PubMed abstract. I have a copy of this article.

Long-term survivors of childhood cancer. The medical consequences of cure. Marina N. Pediatr Clin North Am 1997 Aug;44(4):1021-42. PubMed abstract. I have a copy of this article.

Second primary cancers after childhood cancer. BMJ 1996;312:861-862 (6 April). Leslie L Robison. An Online Editorial. Note: this links to several good references.

Altered mineral metabolism and bone mass in children during treatment for acute lymphoblastic leukemia. alton JM, Atkinson SA, Fraher L, Webber C, Gill GJ, Dawson S, Barr RD. J Bone Miner Res. 1996 Nov;11(11):1774-83. PubMed abstract.

Bibliography - Neurocognitive Function

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Maru Barrera, Amanda K. Shaw, Kathy N. Speechley, Elizabeth Maunsell, Lisa Pogany, M.Sc. Cancer Volume 104, Issue 8 , Pages 1751 - 1760. Abstract.

A bibliography of journal articles on neurocognitive function after cancer treatment in kids. This can be a good list to have when dealing with the bureaucracy in setting up an IEP. Nancy Keene sent me this list in August 2000. It's not typed into a browser window, it's scanned in, so you have to load in each page one at a time.

The Jan/Feb 2005 Journal of Pediatric Psychology has several articles on this topic. You can read the contents/abstracts on their web site: Journal of Pediatric Oncology. Especially: Neurocognitive Interventions for children and Adolescents Surviving Cancer (Butler, R and Mulhern, R).

Educational Issues in Childhood Cancer, Armstrong, F.D., Horn, Marianna. School Psychology Quarterly Vol 10, No. 4, 1995 pp 292-304

Function-Specific Neuropsychological Assessment, Mulhern, Raymond, et al, Medical and Pediatric Oncology Supplement 1:34-40 (1998) (lists all the test used in a good workup--important! -N Keene) (no abstract available on PubMed)

Neurobehavioural Issues in Childhood Cancer, Armstrong, F.D., et al. School Psychology Review Vol 28, No 2, pp 194-203 1999. (talks about interventions -N Keene)

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