Resources and information for parents of children with cancer . . . by parents of children with cancer.

this page last modified

Cytogenetic Studies of Childhood Cancers

Current biotechnology methods enable doctors and researchers to study the DNA of cancer cells. Sometimes they can pinpoint an abnormality in a child's cancer cells; sometimes this abnormality is known from previous studies to be either a good or bad prognostic factor, and sometimes they are only monitoring the DNA abnormality, observing the progression of the cancer, and writing it down for future reference.

The following links to web sites will help parents get up to snuff on what they need to know to be able to have an intelligent conversation with their child's oncologist. The primary focus of this Web page are the translocations in leukemia. (Author's primary interest.) However, some of the background and links pertain to all childhood cancers.

Chromosome Deletion Outreach, Inc.

Introduction to Chromosome Abnormalities

From the St. Francis Health Services Cytogenics Lab in Colorado Springs, Colorado. Start here for a background primer in chromosome nomenclature, with answers (including good graphics) to the following:

American Society of Hematology

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Atlas, search by abnormality or by chromosome number, links to other databases

Educational items: what the abnormalities are, descriptions of malignant blood disorders

Cytogenetic/clinical entities in haematology

This page on the site is a list of known translocations.

Leukemia Gene Database (LeGenD)

"A database of Leukemia genes (LeGenD) is developed to help the Biological and Medical Sciences community to easily access all information on the genes that are involved in Leukemia. The information about these genes is stored in a simple semi-structured database and can be accessed freely through a WWW interface." This site is a little tough for the lay person to get around.

National Cancer Institute - Cancer Genome Anatomy Project

Search for chromosomal abnormalities by different criteria. If you put acute lymphoblastic leukemia in the search box, you get a list of all known ALL abnormalities with links to more information/abstracts on each.

University of Virginia, Health Science System

Leukemia: Laboratory Evaluation - Karyotyping

Pages from Childhood Leukemias, Ching-Hon Pui, editor.

Recurrent chromosomal changes in childhood ALL

Distribution of translocation-associated oncogenes in childhood ALL and Genes affected by chromosomal breakpoints in ALL.

Glossary of Genetic Terms

On the NIH National Human Genome Research Institute site.

Dictionary of Genetic Terms

Genomics and its impact on medicine and society.

General Disclaimer

These pages are intended for informational purposes only and are not intended to render medical advice. The information provided on Ped Onc Resource Center should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you suspect your child has a health problem, you should consult your health care provider.

about this site | privacy statement | terms of use | contact