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Acute Lymphoblastic Leukemia, ALL
Note: This section has health/medical information. It was not written by a health care professional. Please follow the link below for the medical information sources that were used as references for the entire ALL section. Individual pages in this section will list specific references as appropriate.
This section on ALL is the most comprehensive disease section on this web site because it is the type of cancer that most interests your author. The information presented falls into several sections as outlined below.
Classification of ALL
How ALL is classified into subtypes and how it is characterized by current clinical tests:
- Types of ALL: pre-B, B, and T cell leukemias and how they determine this
- Molecular characterization of ALL: karyotypes and cytogenetics: discussion of hyper/hypodiploidy, translocations, point mutations, deletions, list of the translocations that have known prognostic factors
Treatment protocols and clinical trials
Treatment protocols and the role of clinical trials in the treatment of ALL; how patients are directed to the different available trials by the details of their disease:
- Clinical trials/protocols for ALL: background and general information about protocols and trials; prognostic factors that direct treatment; author's essay on learning about prognostic factors
- ALL trial listing: lengthy list of current/past trials and lay outlines of each
New Treatments and Treatment Directions in the Pipeline
Targeted Therapies for Childhood ALL. Article written by the author of this website, 2010.
Recently identified genetic alterations in childhood ALL and the TARGET iniative. Article written by the author of this website, 2010.
Journal articles/news releases of possible new treatments. Last updated 12/2015.
Relapsed ALL is covered on the web author's other web site, all-kids.org. This special section was written in response to posts to the ALL-kids and ALL-kids-relapsed e-mail lists. Parents wanted to know what questions to ask at relapse.
- Questions to ask at relapse
- Chemotherapy vs transplant as treatment for relapsed ALL
- Protocols for relapsed ALL, past and current (2007)
- Questions to ask the transplant team
- Bibliography of journal articles on relapsed ALL
Minimal residual disease - MRD
Probably a lot more than you want to know about MRD; you can always stop at the first page and the introduction for the basics.
Environmental causes of leukemia
Who is studying the epidemiology of ALL and what they have found out.
Bibliography of pertinent/interesting journal articles on ALL.
- NCI section on ALL on the cancer.gov site. This is so important that I have a navigation link to it on each ALL page.
- ASCO meetings, abstracts. A good place to start research into the latest treatments for ALL and relapsed ALL.
- Medscape discussion on ALL
- St. Jude's cure4kids section (requires registration). Slide presentations, abstracts, more on the latest research in ALL (and other cancers).
- Also see the leukemia links on the leukemia page on this web site.
These pages are intended for informational purposes only and are not intended to render medical advice. The information provided on Ped Onc Resource Center should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you suspect your child has a health problem, you should consult your health care provider.